ArticlePlant molecular biology2017
Methylglyoxal detoxification by a DJ-1 family protein provides dual abiotic and biotic stress tolerance in transgenic plants.
Article in Plant molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Control of heat and oxidative stress adaptation by the DJ-1 paralogs in Arabidopsis thaliana.Plant molecular biology · 2025Article
- Synthesis of transcriptomic studies reveals a core response to heat stress in abalone (genus Haliotis).BMC genomics · 2025Article
- Role of methylglyoxal and glyoxalase in the regulation of plant response to heavy metal stress.Plant cell reports · 2024Review
- Article
- Article
- Novel regulators of mitochondrial genome integrity.Journal of biosciences · 2023Article
- Glyoxalase I activity affects Arabidopsis sensitivity to ammonium nutrition.Plant cell reports · 2022Article
- Transcriptional Response of Candida auris to the Mrr1 Inducers Methylglyoxal and Benomyl.mSphere · 2022Article
- Effector-mediated plant-virus-vector interactions.The Plant cell · 2022Review
- Glycation damage to organelles and their DNA increases during maize seedling development.Scientific reports · 2022Article
- Tracing the Evolution of Plant Glyoxalase III Enzymes for Structural and Functional Divergence.Antioxidants (Basel, Switzerland) · 2021Article
- Quantification of Methylglyoxal Levels in Cowpea Leaves in Response to Cowpea Aphid Infestation.Bio-protocol · 2020Article
- AcDCXR Is a Cowpea Aphid Effector With Putative Roles in Altering Host Immunity and Physiology.Frontiers in plant science · 2020Article
- Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil.Scientific reports · 2019Article
- Bifunctional Chloroplastic DJ-1B fromAntioxidants (Basel, Switzerland) · 2019Article
- Genome-wide dissection and expression profiling of unique glyoxalase III genes in soybean reveal the differential pattern of transcriptional regulation.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylglyoxal (MG) is a key signaling molecule resulting from glycolysis and other metabolic pathways. During abiotic stress, MG levels accumulate to toxic levels in affected cells. However, MG is routinely detoxified through the action of DJ1/PARK7/Hsp31 proteins that are highly conserved across kingdoms and mutations in such genes are associated with neurodegenerative diseases. Here, we report for the first time that, similar to abiotic stresses, MG levels increase during biotic stresses in plants, likely contributing to enhanced susceptibility to a wide range of stresses. We show that overexpression of yeast Heat shock protein 31 (Hsp31), a DJ-1 homolog with robust MG detoxifying capabilities, confers dual biotic and abiotic stress tolerance in model plant Nicotiana tabacum. Strikingly, overexpression of Hsp31 in tobacco imparts robust stress tolerance against diverse biotic stress inducers such as viruses, bacteria and fungi, in addition to tolerance against a range of abiotic stress inducers. During stress, Hsp31 was targeted to mitochondria and induced expression of key stress-related genes. These results indicate that Hsp31 is a novel attractive tool to engineer plants against both biotic and abiotic stresses.
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