Evidence map›Paper›PMID 28444479›Full record

ArticleBiogerontology2017

The role of gender and labour status in immunosenescence of 65+ Polish population.

Magdalena Dudkowska, Dorota Janiszewska, Anna Karpa, Katarzyna Broczek, Michal Dabrowski, Ewa Sikora

Erratum issuedAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biogerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Magdalena DudkowskaLaboratory of Molecular Bases of Aging, Department of Biochemistry, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur Str. 3, 02-093, Warsaw, Poland. m.dudkowska@nencki.gov.pl.
Dorota JaniszewskaLaboratory of Molecular Bases of Aging, Department of Biochemistry, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur Str. 3, 02-093, Warsaw, Poland.
Anna KarpaLaboratory of Molecular Bases of Aging, Department of Biochemistry, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur Str. 3, 02-093, Warsaw, Poland.
Katarzyna BroczekLaboratory of Bioinformatics, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur Str. 3, 02-093, Warsaw, Poland.
Michal DabrowskiDepartment of Geriatrics, Medical University of Warsaw, Oczki Str. 4, 02-007, Warsaw, Poland.
Ewa SikoraLaboratory of Molecular Bases of Aging, Department of Biochemistry, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur Str. 3, 02-093, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Women are living longer than men and it seems that one of the reasons could be better immune system of females. In Poland, contrary to many European countries, women retire earlier than men, namely at 60 and 65, respectively. We asked the question how the gender and labour status were interconnected with some immunological parameters included in the so called immune risk profile (IRP), such as CD4+/CD8+ ratio, percentage of CD8+CD28-, and NK, and the level of circulating cytokines. A total of 92 men and 100 women past the retirement age, namely 65-74 years old, still working or not, were examined. We have found statistically significant lower percentage of CD8+CD28- cells and non-statistically significant higher CD4+/CD8+ ratio in women, whereas the percentage of NK was higher in men. Moreover, the percentage of CD8+CD28- cells was negatively correlated with the CD4+/CD8+ ratio and the concentration of IL8 was positively correlated with the concentration of IL10 both in men and women. In men, the level of IL10 was higher than in women. Altogether, we found that gender, but not labour status, influences immunosenescence of the examined population of 65-74 years old Polish people.

Indexed as

EmploymentImmunosenescenceAgedAge FactorsAgingCD28 AntigensCD4-CD8 RatioCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansInterleukin-10Interleukin-8Killer Cells, NaturalMaleRetirementCD28 AntigensCXCL8 protein, humanIL10 protein, humanInterleukin-10Interleukin-8CD8+CD28−Human ageingIL10IL8Immune risk profileT-cells

Identifiers

PMID28444479
PMCPMC5514219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.