ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2017
The activity of the rectal gland of the North Pacific spiny dogfish Squalus suckleyi is glucose dependent and stimulated by glucagon-like peptide-1.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Involvement of sodium-glucose cotransporter-1 activities in maintaining oscillatory ClJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Diagnostic agreement between three point-of-care glucose and β-hydroxybutyrate meters and reference laboratory methods in stingrays.Frontiers in veterinary science · 2023Article
- Sustained endocrine and exocrine function in the pancreas of the Pacific spiny dogfish post-feeding.Fish physiology and biochemistry · 2022Article
- Cortisol and Dexamethasone Mediate Glucocorticoid Actions in the Lesser Spotted Catshark (Biology · 2021Article
- Molecular characterization and nutritional regulation of sodium-dependent glucose cotransporter 1 (Sglt1) in blunt snout bream (Megalobrama amblycephala).Scientific reports · 2021Article
- Sugar uptake, metabolism, and chloride secretion in the rectal gland of the spiny dogfishAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elasmobranchs possess a specialised organ, the rectal gland, which is responsible for excreting sodium chloride via the posterior intestine. Previous work has indicated that the gland may be activated by a number of hormones, some of which are likely related to the salt or volume loads associated with feeding. Furthermore, evidence exists for the gland being glucose dependent which is atypical for an elasmobranch tissue. In this study, the presence of sodium-glucose co-transporters (SGLTs) in the rectal gland and their regulation by feeding were investigated. In addition, the hypothesis of glucose dependence was examined through the use of glucose transporter (GLUT and SGLT) inhibitors, phlorizin, Indinavir, and STF-31 and their effect on secretion by the rectal gland. Finally, the effects on rectal gland activity of insulin, glucagon, and glucagon-like peptide-1, hormones typically involved in glucoregulation, were examined. The results showed that sglt1 mRNA is present in the gland, and there was a significant reduction in sglt1 transcript abundance 24 h post-feeding. An almost complete suppression of chloride secretion was observed when glucose uptake was inhibited, confirming the organ's glucose dependence. Finally, perfusion with dogfish GLP-1 (10 nmol L
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.