ArticleHerz2018
Cerebral dopamine neurotrophic factor protects H9c2 cardiomyocytes from apoptosis.
Article in Herz, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Correlation between serum cerebral dopamine neurotrophic factor levels and severity of coronary artery lesions in acute myocardial infarction.Journal of thoracic disease · 2026Article
- An extensive β1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies.JCI insight · 2023Article
- Beneficial behavioral effects of chronic cerebral dopamine neurotrophic factor (CDNF) infusion in the N171-82Q transgenic model of Huntington's disease.Scientific reports · 2023Article
- CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival.International journal of molecular sciences · 2022Article
- Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism.Molecular psychiatry · 2022Review
- New Cardiomyokine Reduces Myocardial Ischemia/Reperfusion Injury by PI3K-AKT Pathway Via a Putative KDEL-Receptor Binding.Journal of the American Heart Association · 2021Article
- Trophic activities of endoplasmic reticulum proteins CDNF and MANF.Cell and tissue research · 2020Review
- Quantitative analysis on secretion level of CDNF regulated by two key α-helices in CDNF protein.Cell biology international · 2019Article
- Trophic Factors in Inflammation and Regeneration: The Role of MANF and CDNF.Frontiers in physiology · 2018Article
- The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?BioMed research international · 2018Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCerebral dopamine neurotrophic factor (CDNF) has been studied in animal models of Parkinson's disease, where it was shown to repair and protect dopamine neurons. Alongside its neurotrophic activity, it can also localize in the endoplasmic reticulum (ER) acting as an ER stress response (ERSR) protein to maintain ER homeostasis. Since ER stress plays a major role in the development and progression of cardiovascular diseases, we investigated the role of CDNF in cardiomyocytes during ER stress. MATERIAL AND
methodsInitially, the expression of CDNF was tested by treating H9c2 cells with various concentrations of tunicamycin (TM) and performing reverse-transcriptase polymerase chain reaction and Western blotting. To evaluate the overexpression of CDNF in cardiomyocytes, H9c2 cells were transfected with pcDNA-CDNF and analyzed by Western blotting and indirect immunofluorescence microscopy. The effects of CDNF on cardiomyocytes during ER stress were analyzed with CCK-8 method and TUNEL staining using cells transfected with pcDNA-CDNF or pcDNA3.1. The percentage of TUNEL-positive cells was quantified as the apoptotic level.
resultsOur results showed that CDNF protein expression can be induced by activation of ER stress in cultured cardiomyocytes. Moreover, overexpression of CDNF improved cell viability and protected cardiomyocytes from apoptosis induced by ER stress.
conclusionThe findings presented here contribute toward identifying the physiological functions of CDNF in cardiovascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.