ArticleCerebral cortex (New York, N.Y. : 1991)2018
APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- A cross-sectional analysis of brain structure, pain behaviors, and mental health in persons with surgically confirmed endometriosis.Communications biology · 2025Article
- Cortical thickness and low-grade inflammation moderate the association between depressive symptoms and cognitive function in early widowhood: A preliminary study.Brain, behavior, and immunity · 2025Article
- Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.Neurobiology of aging · 2025Article
- A Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies.Human brain mapping · 2024Article
- Longitudinal changes in gray matter correspond to changes in cognition across the lifespan: implications for theories of cognition.Neurobiology of aging · 2023Article
- Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Lower cortical thickness and increased brain aging in adults with cocaine use disorder.Frontiers in psychiatry · 2023Article
- A comparison of methods to harmonize cortical thickness measurements across scanners and sites.NeuroImage · 2022Article
- A Causal Analysis of the Effect of Age and Sex Differences on Brain Atrophy in the Elderly Brain.Life (Basel, Switzerland) · 2022Article
- Specific and general relationships between cortical thickness and cognition in older adults: a longitudinal study.Neurobiology of aging · 2021Article
- Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.Brain structure & function · 2021Article
- Brain structure and cognitive ability in healthy aging: a review on longitudinal correlated change.Reviews in the neurosciences · 2019Review
- Joint contributions of cortical morphometry and white matter microstructure in healthy brain aging: A partial least squares correlation analysis.Human brain mapping · 2019Article
- Age moderates the relationship between cortical thickness and cognitive performance.Neuropsychologia · 2019Article
- Sex differences in brain aging and predictors of neurodegeneration in cognitively healthy older adults.Neurobiology of aging · 2019Article
- Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- Neurovascular and Cognitive Dysfunction in Hypertension.Circulation research · 2019Review
- Cortisol relates to regional limbic system structure in older but not younger adults.Psychoneuroendocrinology · 2019Article
- Frontoparietal cortical thickness mediates the effect of COMT ValNeurobiology of aging · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
We investigated individual differences in longitudinal trajectories of brain aging in cognitively normal healthy adults from the Seattle Longitudinal Study covering 8 years of longitudinal change (across 5 occasions) in cortical thickness in 249 midlife and older adults (52-95 years old). We aimed to understand true brain change; examine the influence of salient risk factors that modify an individual's rate of cortical thinning; and compare cross-sectional age-related differences in cortical thickness to longitudinal within-person cortical thinning. We used Multivariate Multilevel Modeling to simultaneously model dependencies among 5 lobar composites (Frontal, Parietal, Temporal, Occipital, and Cingulate [CING]) and account for the longitudinal nature of the data. Results indicate (1) all 5 lobar composites significantly atrophied across 8 years, showing nonlinear longitudinal rate of cortical thinning decelerated over time, (2) longitudinal thinning was significantly altered by hypertension and Apolipoprotein-E ε4 (APOEε4), varying by location: Frontal and CING thinned more rapidly in APOEε4 carriers. Notably, thinning of parietal and occipital cortex showed synergistic effect of combined risk factors, where individuals who were both APOEε4 carriers and hypertensive had significantly greater 8-year thinning than those with either risk factor alone or neither risk factor, (3) longitudinal thinning was 3 times greater than cross-sectional estimates of age-related differences in thickness in parietal and occipital cortices.
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