ArticleMolecular biology and evolution2017
Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
- SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program.Molecular biology of the cell · 2025Article
- A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development.Current biology : CB · 2024Article
- A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development.bioRxiv : the preprint server for biology · 2024Article
- More than a decade of genetic research on the Denisovans.Nature reviews. Genetics · 2024Review
- Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone.American journal of biological anthropology · 2023Article
- The contribution of Neanderthal introgression to modern human traits.Current biology : CB · 2022Review
- Article
- Combined RNA/tissue profiling identifies novel Cancer/testis genes.Molecular oncology · 2021Article
- Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs.Nature cell biology · 2021Article
- Quantifying the contribution of Neanderthal introgression to the heritability of complex traits.Nature communications · 2021Article
- Evaluating genetic causes of azoospermia: What can we learn from a complex cellular structure and single-cell transcriptomics of the human testis?Human genetics · 2021Review
- Signals interpreted as archaic introgression appear to be driven primarily by faster evolution in Africa.Royal Society open science · 2020Article
- Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines.Heliyon · 2020Article
- Directing differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Characterisation and localisation of the endocannabinoid system components in the adult human testis.Scientific reports · 2019Article
- Impact and Evolutionary Determinants of Neanderthal Introgression on Transcriptional and Post-Transcriptional Regulation.American journal of human genetics · 2019Article
- Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes.Genes · 2018Review
- Dynamic Copy Number Evolution of X- and Y-Linked Ampliconic Genes in Human Populations.Genetics · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
About 1-6% of the genetic ancestry of modern humans today originates from admixture with archaic humans. It has recently been shown that autosomal genomic regions with a reduced proportion of Neanderthal and Denisovan ancestries (NA and DA) are significantly enriched in genes that are more expressed in testis than in other tissues. To determine whether a cellular segregation pattern would exist, we combined maps of archaic introgression with a cross-analysis of three transcriptomic datasets deciphering the transcriptional landscape of human gonadal cell types. We reveal that the regions deficient in both NA and DA contain a significant enrichment of genes transcribed in meiotic germ cells. The interbreeding of anatomically modern humans with archaic humans may have introduced archaic-derived alleles that contributed to genetic incompatibilities affecting meiosis that were subsequently purged by natural selection.
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