Observational studyNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2018
Intradialytic hypotension, blood pressure changes and mortality risk in incident hemodialysis patients.
Observational study in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Prediction of intradialytic hypotension by machine learning: A systematic review.Journal of nephrology · 2025Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- The Prevalence of Intradialytic Hypotension in Patients on Conventional Hemodialysis: A Systematic Review with Meta-Analysis.American journal of nephrology · 2019Pooled it
- Bradykinin BBMC nephrology · 2023Trial
- Hypertonic Mannitol for the Prevention of Intradialytic Hypotension: A Randomized Controlled Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Trial
- Effects of sertraline in the prevention of low blood pressure in patients undergoing hemodialysis.Jornal brasileiro de nefrologiaTrial
- The value of pleth variability index in predicting hypotension during maintenance hemodialysis: a prospective observational multicenter study (PVi-HD study).BMC nephrology · 2026Observational
- Accurate prediction of intradialytic hypo- and hypertension in haemodialysis patients: the dual-attention Transformer model.Clinical kidney journal · 2026Article
- Continuous monitoring of relative blood volume allows real-time assessment of intradialytic hypotension risk.Clinical kidney journal · 2026Article
- Intradialytic Hypotensive Episodes are Only Occasionally Associated With Adverse Symptoms.Kidney international reports · 2026Article
- Impact of Left Ventricular Geometry on All-Cause Mortality in Patients Undergoing Hemodialysis: A Longitudinal Observational Study.Kidney360 · 2026Observational
- Intra-Session recurrence in intradialytic hypotension prediction: evaluation implications and recurrence-aware modeling.Frontiers in digital health · 2026Article
- Machine Learning-Based Prediction of Life-Threatening Complications During Hemodialysis in Hospitalized Patients With Poor General Conditions.Artificial organs · 2026Article
- Intradialytic hypotension is severely underreported by intermittent blood pressure readings.Clinical kidney journal · 2026Article
- Prediction of intradialytic hypotension based on heart rate variability and skin sympathetic nerve activity using LASSO-enabled feature selection: a two-center study.Renal failure · 2025Article
- Uremic toxins removal and iron status: a medium-term comparison between 4 dialysis techniques (EMPIRE study).Renal failure · 2025Observational
- Predicting blood pressure variability in hemodialysis using an explainable boosting machine model.Clinical kidney journal · 2025Article
- The Effect of Dialysate Sodium on Endothelial Injury and Microcirculatory Dysfunction.Kidney360 · 2025Article
- Clinical challenges and individualized approaches to dialysis therapy in older adults.The Korean journal of internal medicine · 2025Review
- Effectiveness of blood volume change-guided ultrafiltration control (BV-UFC) in hemodialysis: a crossover comparative study.Clinical kidney journal · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Background: Intradialytic hypotension (IDH) occurs frequently in maintenance hemodialysis (HD) patients and may be associated with higher mortality. We hypothesize that nadir intradialytic systolic blood pressure (niSBP) is inversely related to death risk while iSBP change (Δ) and IDH frequency are incrementally associated with all-cause mortality. Methods: In a US-based cohort of 112 013 incident HD patients over a 5-year period (2007-11), using niSBP, ΔiSBP (pre-HD SBP minus niSBP) and IDH frequency (proportion of HD treatments with niSBP <90 mmHg) within the first 91 days of HD, we examined mortality-predictability at 1, 2 and 5 years using Cox models and restricted cubic splines adjusted for case-mix, comorbidities and laboratory covariates. Results: We observed that niSBP of <90 and ≥140 mmHg had a 5-year mortality hazard ratio (HR) (95% confidence interval) of 1.57 (1.47-1.67) and 1.25 (1.18-1.33), respectively, compared with niSBP 110 to <120 mmHg. ΔiSBP of <15 and ≥50 compared with 21-30 mmHg had mortality HR of 1.31 (1.26-1.37) and 1.32 (1.24-1.39), respectively. Among patients with >40% IDH frequency, we observed a mortality HR of 1.49 (1.42-1.57) compared with 0% IDH frequency in fully adjusted models. These associations were robust at 1 and 2 years of follow-up. Conclusion: In conclusion, we observed a U-shaped association between niSBP and ΔiSBP and mortality and a direct linear relationship between IDH frequency and mortality. Our findings lend some prognostic insight of HD blood pressure and hemodynamics, and have the potential to guide blood pressure management strategies among the HD population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.