Evidence map›Paper›PMID 28444321›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2017

Evidence of Altered Brain Responses to Nicotine in an Animal Model of Attention Deficit/Hyperactivity Disorder.

Guillaume L Poirier, Wei Huang, Kelly Tam, Joseph R DiFranza, Jean A King

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Electronic Cigarette Harms: Aggregate Evidence Shows Damage to Biological Systems.International journal of environmental research and public health · 2023
    Review
  4. Reducing the Prevalence of Smoking: Policy Measures and Focusing on Specific Populations.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guillaume L PoirierCenter for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School,Worcester, MA.
Wei HuangCenter for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School,Worcester, MA.
Kelly TamCenter for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School,Worcester, MA.
Joseph R DiFranzaCenter for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA.
Jean A KingCenter for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA.
University of Massachusetts Chan Medical School · US

Funding

4.7T Magnet System UpgradeS10OD018132 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KING, JEAN A · 2014 to 2014
$598k
NIH HHS S10 OD018132
6 · The paper itself

Abstract

introductionIndividuals with attention deficit/hyperactivity disorder (ADHD) are susceptible to earlier and more severe nicotine addiction. To shed light on the relationship between nicotine and ADHD, we examined nicotine's effects on functional brain networks in an animal model of ADHD.

methodsAwake magnetic resonance imaging was used to compare functional connectivity in adolescent (post-natal day 44 ± 2) males of the spontaneously hypertensive rat (SHR) strain and two control strains, Wistar-Kyoto and Sprague-Dawley (n = 16 each). We analyzed functional connectivity immediately before and after nicotine exposure (0.4 mg/kg base) in naïve animals, using a region-of-interest approach focussing on 16 regions previously implicated in reward and addiction.

resultsRelative to the control groups, the SHR strain demonstrated increased functional connectivity between the ventral tegmental area (VTA) and retrosplenial cortex in response to nicotine, suggesting an aberrant response to nicotine. In contrast, increased VTA-substantia nigra connectivity in response to a saline injection in the SHR was absent following a nicotine injection, suggesting that nicotine normalized function in this circuit.

conclusionsIn the SHR, nicotine triggered an atypical response in one VTA circuit while normalizing activity in another. The VTA has been widely implicated in drug reward. Our data suggest that increased susceptibility to nicotine addiction in individuals with ADHD may involve altered responses to nicotine involving VTA circuits. IMPLICATIONS: Nicotine addiction is more common among individuals with ADHD. We found that two circuits involving the VTA responded differently to nicotine in animals that model ADHD in comparison to two control strains. In one circuit, nicotine normalized activity that was abnormal in the ADHD animals, while in the other circuit nicotine caused an atypical brain response in the ADHD animals. The VTA has been implicated in drug reward. Our results would be consistent with an interpretation that nicotine may normalize abnormal brain activity in ADHD, and that nicotine may be more rewarding for individuals with ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityBrainDisease Models, AnimalNicotineAnimalsBrain ChemistryMaleRatsRats, Inbred WKYRats, Sprague-DawleyNicotine

Identifiers

PMID28444321
PMCPMC5896460
OpenAlexW2605665133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.