ArticleGenome biology and evolution2017
Whole-Genome Sequencing of Seven Strains of Staphylococcus lugdunensis Allows Identification of Mobile Genetic Elements.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02026895 (Virulence of Staphylococcus Lugdunensis in Severe Infections), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Virulence of Staphylococcus Lugdunensis in Severe Infections
Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
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- Searching for Virulence Factors amongInternational journal of molecular sciences · 2023Article
- Methacrylate Cationic Nanoparticles Activity against Different Gram-Positive Bacteria.Antibiotics (Basel, Switzerland) · 2023Article
- Identification of New Drug Target inBioengineering (Basel, Switzerland) · 2022Article
- Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands.mSphere · 2021Article
- Comparative Genomic Analyses Reveal Potential Factors Responsible for the ST6 Oxacillin-ResistantFrontiers in microbiology · 2021Article
- Coagulase-Negative Staphylococci Pathogenomics.International journal of molecular sciences · 2019Review
- Comparative Genome Analysis ofFrontiers in microbiology · 2019Article
- Comparative genomic analysis of Staphylococcus lugdunensis shows a closed pan-genome and multiple barriers to horizontal gene transfer.BMC genomics · 2018Article
- Culture-Facilitated Comparative Genomics of the Facultative Symbiont Hamiltonella defensa.Genome biology and evolution · 2018Article
- Article
- Is Staphylococcus lugdunensis Significant in Clinical Samples?Journal of clinical microbiology · 2017Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coagulase negative staphylococci are normal inhabitant of the human skin flora that account for an increasing number of infections, particularly hospital-acquired infections. Staphylococcus lugdunensis has emerged as a most virulent species causing various infections with clinical characteristics close to what clinicians usually observe with Staphylococcus aureus and both bacteria share more than 70% of their genome. Virulence of S. aureus relies on a large repertoire of virulence factors, many of which are encoded on mobile genetic elements. S. lugdunensis also bears various putative virulence genes but only one complete genome with extensive analysis has been published with one prophage sequence (φSL2) and a unique plasmid was previously described. In this study, we performed de novo sequencing, whole genome assembly and annotation of seven strains of S. lugdunensis from VISLISI clinical trial. We searched for the presence of virulence genes and mobile genetics elements using bioinformatics tools. We identified four new prophages, named φSL2 to φSL4, belonging to the Siphoviridae class and five plasmids, named pVISLISI_1 to pVISLISI_5. Three plasmids are homologous to known plasmids that include, amongst others, one S. aureus plasmid. The two other plasmids were not described previously. This study provides a new context for the study of S. lugdunensis virulence suggesting the occurrence of several genetic recombination' with other staphylococci.
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