ArticleCerebral cortex (New York, N.Y. : 1991)2018
Genetic Influence on the Sulcal Pits: On the Origin of the First Cortical Folds.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 83 citations in OpenAlex.
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- Long-term effects of preterm birth on cortical folding trajectories in early childhood.Brain communications · 2026Article
- Predictive value of foetal superior temporal sulcus asymmetry for neonatal speech discrimination.Brain communications · 2026Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Sulcal pits as potential markers of early sex-related human brain differences in healthy adults.Biology of sex differences · 2025Article
- Article
- Gyral peak variations between HCP and CHCP: functional and structural implications.Brain structure & function · 2025Article
- A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Defining putative tertiary sulci in lateral prefrontal cortex in chimpanzees using human predictions.Brain structure & function · 2024Article
- Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations.AIMS neuroscience · 2024Article
- Evaluation of surface-based hippocampal registration using ground-truth subfield definitions.eLife · 2023Article
- Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability.Brain structure & function · 2023Article
- Gyral peaks and patterns in human brains.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A revised perspective on the evolution of the lateral frontal cortex in primates.Science advances · 2023Article
- Development of Human Lateral Prefrontal Sulcal Morphology and Its Relation to Reasoning Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study®.Behavior genetics · 2023Article
- Article
- Quantification of sulcal emergence timing and its variability in early fetal life: Hemispheric asymmetry and sex difference.NeuroImage · 2022Article
- Gyral peaks: Novel gyral landmarks in developing macaque brains.Human brain mapping · 2022Article
- Cortical development coupling between surface area and sulcal depth on macaque brains.Brain structure & function · 2022Article
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9 authors at 3 institutions in 1 country.
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Abstract
The influence of genes on cortical structures has been assessed through various phenotypes. The sulcal pits, which are the putative first cortical folds, have for long been assumed to be under tight genetic control, but this was never quantified. We estimated the pit depth heritability in various brain regions using the high quality and large sample size of the Human Connectome Project pedigree cohort. Analysis of additive genetic variance indicated that their heritability ranges between 0.2 and 0.5 and displays a regional genetic control with an overall symmetric pattern between hemispheres. However, a noticeable asymmetry of heritability estimates is observed in the superior temporal sulcus and could thus be related to language lateralization. The heritability range estimated in this study reinforces the idea that cortical shape is determined primarily by nongenetic factors, which is consistent with the important increase of cortical folding from birth to adult life and thus predominantly constrained by environmental factors. Nevertheless, the genetic cues, implicated with various local levels of heritability in the formation of sulcal pits, play a fundamental role in the normal gyral pattern development. Quantifying their influence and identifying the underlying genetic variants would provide insight into neurodevelopmental disorders.
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