ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
The Effect of a Piperacillin/Tazobactam Shortage on Antimicrobial Prescribing and Clostridium difficile Risk in 88 US Medical Centers.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Drug supply chain disruptions and outpatient medication shortages in the Veterans Health Administration, 2017-2020.Exploratory research in clinical and social pharmacy · 2026Article
- Supply Chain Events and Risk of Drug Shortage in Canada.JAMA network open · 2026Article
- The association between drug shortages and prices across 74 countries: uncovering global access inequities.BMJ global health · 2025Article
- Impact of Antibiotic Shortages on Antibiotic Utilisation in the Community.Pharmacoepidemiology and drug safety · 2025Article
- Review
- Lessons learned from a diagnostic stewardship intervention in response to a blood culture bottle supply shock.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Policy options for sustainable access to off-patent antibiotics in Europe.npj antimicrobials and resistance · 2024Review
- Cheaper is not always better: Drug shortages in the United States and a value-based solution to alleviate them.Journal of managed care & specialty pharmacy · 2024Article
- Drug Shortages Prior to and During the COVID-19 Pandemic.JAMA network open · 2024Article
- A pharmaceutical policy accident: collision of shareholder capitalism and Chinese state capitalism driving the shortage of an essential antibiotic.Journal of pharmaceutical policy and practice · 2024Article
- Consecutive antibiotic shortages highlight discrepancies between microbiology and prescribing practices for intra-abdominal infections.Antimicrobial agents and chemotherapy · 2023Article
- The impact of carbapenem shortage and stewardship countermeasures on antimicrobial practice at a tertiary care center.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- The perfect storm: respiratory viral surges and anti-infective shortages.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Pharmacy practice in emergency response during the COVID-19 pandemic: Lessons from Australia.Research in social & administrative pharmacy : RSAP · 2022Review
- Shortage of essential antimicrobials: a major challenge to global health security.BMJ global health · 2021Review
- Effects of the cefazolin shortage on the sales, cost, and appropriate use of other antimicrobials.BMC health services research · 2021Article
- Impact of Cefazolin Shortage on Clinical Outcomes of Adult Patients with Bacteremia Caused by Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2021Article
- Comparison of therapy with β-lactam/β-lactamase inhibitor combinations or carbapenems for bacteraemia of nonurinary source caused by ESBL-producing Escherichia coli or Klebsiella pneumoniae.Annals of clinical microbiology and antimicrobials · 2021Article
- Drug Shortage: Causes, Impact, and Mitigation Strategies.Frontiers in pharmacology · 2021Review
- Impact of an antimicrobial stewardship programme on antimicrobial utilization and the prevalence of MDRJAC-antimicrobial resistance · 2020Article
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6 authors.
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Abstract
backgroundAnti-infective shortages are a pervasive problem in the United States. The objective of this study was to identify any associations between changes in prescribing of antibiotics that have a high risk for CDI during a piperacillin/tazobactam (PIP/TAZO) shortage and hospital-onset Clostridium difficile infection (HO-CDI) risk in 88 US medical centers.
methodsWe analyzed electronically captured microbiology and antibiotic use data from a network of US hospitals from July 2014 through June 2016. The primary outcome was HO-CDI rate and the secondary outcome was changes in antibiotic usage. We fit a Poisson model to estimate the risk of HO-CDI associated with PIP/TAZO shortage that were associated with increased high-risk antibiotic use while controlling for hospital characteristics.
resultsA total of 88 hospitals experienced PIP/TAZO shortage and 72 of them experienced a shift toward increased use of high-risk antibiotics during the shortage period. The adjusted relative risk (RR) of HO-CDI for hospitals experiencing a PIP/TAZO shortage was 1.03 (95% confidence interval [CI], .85-1.26; P = .73). The adjusted RR of HO-CDI for hospitals that both experienced a shortage and also showed a shift toward increased use of high-risk antibiotics was 1.30 (95% CI, 1.03-1.64; P < .05).
conclusionsHospitals that experienced a PIP/TAZO shortage and responded to that shortage by shifting antibiotic usage toward antibiotics traditionally known to place patients at greater risk for CDI experienced greater HO-CDI rates; this highlights an important adverse effect of the PIP/TAZO shortage and the importance of antibiotic stewardship when mitigating drug shortages.
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