Evidence map›Paper›PMID 28444082›Full record

ArticleEinstein (Sao Paulo, Brazil)2017

II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies.

Ekaterini Simões Goudouris, Almerinda Maria do Rego Silva, Aluce Loureiro Ouricuri, Anete Sevciovic Grumach, Antonio Condino-Neto, Beatriz Tavares Costa-Carvalho, Carolina Cardoso Prando, Cristina Maria Kokron, Dewton de Moraes Vasconcelos, Fabíola Scancetti Tavares and 5 more

Erratum issued Registry-linked trialOpen access · diamondAbstract readConsensus Statement
In one paragraph

Article in Einstein (Sao Paulo, Brazil), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06962631 (V-IMMUNE® for Immune Thrombocytopenia), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06962631 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

V-IMMUNE® for Immune Thrombocytopenia: A Prospective Multicenter Study to Evaluate the Efficacy and Safety of Human Immunoglobulin in Adult and Pediatric Participants With Immune Thrombocytopenia. TIP Study

TypeinterventionalSponsorOn Pharma Importadora, Exportadora e Distribuidora de Medicamentos LTDA.Ran2025 to 2027Enrolled31ConditionsImmune Thrombocytopenia (ITP)Arms5% (5g/100 ml) intravenous immunoglobin
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. NEUROENDOCRINE TUMOR IN A CHILD WITH COMMON VARIABLE IMMUNODEFICIENCY.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020
    Article
  2. Article
  3. Review
  4. Combined immunodeficiencies.Jornal de pediatria
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Ekaterini Simões GoudourisUniversidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Almerinda Maria do Rego SilvaUniversidade Federal de Pernambuco, Recife, PE, Brazil.
Aluce Loureiro OuricuriHospital Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Anete Sevciovic GrumachFaculdade de Medicina do ABC, Santo André, SP, Brazil.
Antonio Condino-NetoUniversidade de São Paulo, São Paulo SP, Brazil.
Beatriz Tavares Costa-CarvalhoUniversidade Federal de São Paulo, São Paulo, SP, Brazil.
Carolina Cardoso PrandoHospital Infantil Pequeno Príncipe, Curitiba, PR, Brazil.
Cristina Maria KokronHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Dewton de Moraes VasconcelosHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Fabíola Scancetti TavaresHospital de Base do Distrito Federal, Brasília, DF, Brazil.
Gesmar Rodrigues Silva SegundoUniversidade Federal de Uberlândia, Uberlândia, MG, Brazil.
Irma Cecília BarretoCentro Universitário do Estado do Pará, Belém, PA, Brazil.
Mayra de Barros DornaHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Myrthes Anna BarrosHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Wilma Carvalho Neves ForteFaculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brazil.
Universidade de São Paulo · BRCentro Universitário do Pará · BRFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRFaculdade de Medicina do ABC · BRHospital de Base · BRHospital Erasto Gaertner · BRHospital Federal dos Servidores do Estado · BRUniversidade Federal de Pernambuco · BRUniversidade Federal de São Paulo · BRUniversidade Federal de Uberlândia · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010. The document presents new knowledge about the indications and efficacy of immunoglobulin therapy in primary immunodeficiencies, relevant production-related aspects, mode of use (routes of administration, pharmacokinetics, doses and intervals), adverse events (major, prevention, treatment and reporting), patient monitoring, presentations available and how to have access to this therapeutic resource in Brazil.

Indexed as

Administration, CutaneousAdministration, IntravenousBrazilHumansImmunoglobulinsImmunologic Deficiency SyndromesImmunologic FactorsTreatment OutcomeImmunoglobulinsImmunologic Factors

Identifiers

PMID28444082
PMCPMC5433300
OpenAlexW2605912034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.