ArticleScientific reports2017
Differences in peripheral sensory input to the olfactory bulb between male and female mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants.Nature communications · 2025Pooled it
- Olfactory dysfunction in aging and neurodegenerative diseases.Ageing research reviews · 2021Pooled it
- Olfactory Bulb Volume Reflects Olfactory Dysfunction and Network Organization: Insights From the Population-Based Rhineland Study.International forum of allergy & rhinology · 2026Article
- Sex differences in hedonic feeding and characterizing the effects of antibiotic-induced microbiome disruption.Research square · 2026Article
- Atlas of GLP-1 expression in the mouse brain: Neuroanatomical basis for metabolic and psychiatric effects.Brain medicine : from neurons to behavior and better health · 2026Article
- Sex differences in olfactory behavior and neurophysiology in Long Evans rats.Journal of neurophysiology · 2025Article
- Article
- Pheromone Perception in Fish: Mechanisms and Modulation by Internal Status.Integrative and comparative biology · 2023Review
- A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus.Nature communications · 2023Article
- Is Olfactory Testing a Useful Diagnostic Tool to Identify SARS-CoV-2 Infections Early? A Cross-Sectional and Longitudinal Analysis.Journal of clinical medicine · 2023Article
- Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system.Cell and tissue research · 2023Review
- Odor exploration behavior of the domestic pig (Frontiers in behavioral neuroscience · 2023Article
- Enhanced autophagy inAutophagy · 2022Article
- Horse odor exploration behavior is influenced by pregnancy and age.Frontiers in behavioral neuroscience · 2022Article
- Effect of Sensory Deprivation of Nasal Respiratory on Behavior of C57BL/6J Mice.Brain sciences · 2021Article
- Anxiety-related shifts in smell function in children and adolescents.Chemical senses · 2021Article
- Alterations in odor hedonics in the 5XFAD Alzheimer's disease mouse model and the influence of sex.Behavioral neuroscience · 2020Article
- Factors associated with odour identification in older Indonesian and white Australian adults.Aging clinical and experimental research · 2020Article
- Single Prolonged Stress as a Prospective Model for Posttraumatic Stress Disorder in Females.Frontiers in behavioral neuroscience · 2019Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Female mammals generally have a superior sense of smell than males, but the biological basis of this difference is unknown. Here, we demonstrate sexually dimorphic neural coding of odorants by olfactory sensory neurons (OSNs), primary sensory neurons that physically contact odor molecules in the nose and provide the initial sensory input to the brain's olfactory bulb. We performed in vivo optical neurophysiology to visualize odorant-evoked OSN synaptic output into olfactory bub glomeruli in unmanipulated (gonad-intact) adult mice from both sexes, and found that in females odorant presentation evoked more rapid OSN signaling over a broader range of OSNs than in males. These spatiotemporal differences enhanced the contrast between the neural representations of chemically related odorants in females compared to males during stimulus presentation. Removing circulating sex hormones makes these signals slower and less discriminable in females, while in males they become faster and more discriminable, suggesting opposite roles for gonadal hormones in influencing male and female olfactory function. These results demonstrate that the famous sex difference in olfactory abilities likely originates in the primary sensory neurons, and suggest that hormonal modulation of the peripheral olfactory system could underlie differences in how males and females experience the olfactory world.
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Registered trials
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