Evidence map›Paper›PMID 28443625›Full record

SynthesisNature communications2017

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

Anne E Justice, Thomas W Winkler, Mary F Feitosa, Misa Graff, Virginia A Fisher, Kristin Young, Llilda Barata, Xuan Deng, Jacek Czajkowski, David Hadley and 307 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03766191 (The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children), which is not on this map. Cited by 130 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03766191 nacompletednot on this mapstarted 2019, after this paper: background citation

The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children

TypeinterventionalSponsorTrustees of Dartmouth CollegeRan2019 to 2024Enrolled189ConditionsChildhood ObesityArmsFood Ads, Non-food Ads
3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

317 authors.

Anne E JusticeDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0002-8903-8712
Thomas W WinklerDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.ORCID 0000-0003-0292-5421
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine; St. Louis, Missouri, 63108 USA.
Misa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Virginia A FisherDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Kristin YoungDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0003-0070-6145
Llilda BarataDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine; St. Louis, Missouri, 63108 USA.
Xuan DengDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Jacek CzajkowskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine; St. Louis, Missouri, 63108 USA.
David HadleyPopulation Health Research Institute, St. George's, University of London, London, SW17 0RE, UK.
Julius S NgwaDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Tarunveer S AhluwaliaThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7464-3354
Audrey Y ChuNHLBI Framingham Heart Study, Framingham, Massachusetts, 01702 USA.
Nancy L Heard-CostaNHLBI Framingham Heart Study, Framingham, Massachusetts, 01702 USA.
Elise LimDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Jeremiah PerezDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
John D EicherPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, USA.
Zoltán KutalikInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Luting XueDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Frida RenströmDepartment of Biobank Research, Umeå University, Umeå, Sweden.
Joseph WuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Shafqat AhmadDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts USA.
Tamuno AlfredThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3015GE, The Netherlands.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Amelie BonnefondUniversity of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID, Lille, France.
Jennifer BraggInternal Medicine - Nephrology, University of Michigan, Ann Arbor, Michigan, USA.
Gemma CadbyCentre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Australia.
Martina ChittaniDepartment of Health Sciences, University of Milan,Via A. Di Rudiní, 8 20142, Milano, Italy.
Scott CoggeshallDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Tanguy CorreInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Nese DirekDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Joel ErikssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Krista FischerEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Mathias GorskiDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Marie Neergaard HarderThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Momoko HorikoshiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Tao HuangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Jennifer E HuffmanPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, USA.ORCID 0000-0002-9672-2491
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.ORCID 0000-0002-9672-2547
Johanne Marie JustesenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Leena KinnunenDepartment of Health, National Institute for Health and Welfare, Helsinki, FI-00271 Finland.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0003-0663-7275
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Meena KumariISER, University of Essex, Colchester CO43SQ, UK.
Unhee LimEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-2167-7470
Ani ManichaikulCenter for Public Health Genomics and Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22903, USA.
Jonathan MartenMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Rita P S MiddelbergGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Pau NavarroMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0001-5576-8584
Louis PérusseDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Natalia PervjakovaEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Cinzia SartiDepartment of Social and Health Care, City of Helsinki, Helsinki, Finland.
Albert Vernon SmithIcelandic Heart Association, Kopavogur, Iceland.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3575-5468
Alena StančákováDepartment of Medicine, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Rona J StrawbridgeCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8506-3585
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.ORCID 0000-0002-2991-6392
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore Maryland, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Germany.ORCID 0000-0002-8309-094X
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, The Netherlands.
Sander W van der LaanLaboratory of Experimental Cardiology, Department of Cardiology, Division Heart &Lungs, UMC Utrecht, The Netherlands.ORCID 0000-0001-6888-1404
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.ORCID 0000-0001-8450-3518
Jana V Van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands.ORCID 0000-0002-7943-3153
Sailaja L VedantamDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston Massachusetts 02115, USA.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands.
Jacqueline M VinkDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Loic YengoUniversity of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID, Lille, France.
Weihua ZhangDept Epidemiology and Biostatistics, School of Public Health, Imperical College London, UK.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Martina E ZimmermannDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.ORCID 0000-0002-6916-4404
Niha ZubairDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle Washington USA.
Gonçalo R AbecasisDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Linda S AdairDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Saima AfaqDept Epidemiology and Biostatistics, School of Public Health, Imperical College London, UK.
Uzma AfzalDept Epidemiology and Biostatistics, School of Public Health, Imperical College London, UK.
Stephan J L BakkerDepartment of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
John BeilbyBusselton Population Medical Research Institute, Nedlands, Western Australia 6009, Australia.ORCID 0000-0002-4915-2254
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Sven BergmannDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6785-9034
Reiner BiffarClinic for Prosthetic Dentistry, Gerostomatology and Material Science, University Medicine Greifswald, Germany.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas, USA.
Eric BoerwinkleHuman Genetics Center, The University of Texas Health Science Center, PO Box 20186, Houston, Texas 77225, USA.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Erwin BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
Daniele BragaDepartment of Health Sciences, University of Milan,Via A. Di Rudiní, 8 20142, Milano, Italy.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Ireland.
Steve BuyskeDepartment of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA.ORCID 0000-0001-8539-5416
Harry CampbellUsher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Scotland, UK.
John C ChambersCardiology, Ealing Hospital NHS Trust, Middlesex, UK.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Joanne E CurranSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas, USA.
Gert J de BorstDepartment of Vascular Surgery, Division of Surgical Specialties, UMC Utrecht, The Netherlands.
Anton J M de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands.
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hester M den RuijterLaboratory of Experimental Cardiology, Department of Cardiology, Division Heart &Lungs, UMC Utrecht, The Netherlands.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Anna L ErikssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, UK.
Terrence ForresterTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, JMAAW15 Jamaica.
Karl GertowCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Bruna GiganteUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Nicola GloriosoHypertension and Related Disease Centre, AOU-University of Sassari.
Jian GongDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle Washington USA.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Tanja B GrammerVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Saskia HaitjemaLaboratory of Experimental Cardiology, Department of Cardiology, Division Heart &Lungs, UMC Utrecht, The Netherlands.
Göran HallmansDepartment of Public Health and Clinical Medicine, Section for Nutritional Research, Umeå University, Umeå, Sweden.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tamara B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Maija HassinenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Nicholas D HastieMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Dena HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.
Lucia HindorffDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Lynne J HockingInstitute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
Mette HollenstedThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Oddgeir L HolmenSt. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
Jouke Jan HottengaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Jie HuangDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Joseph HungSchool of Medicine and Pharmacology, The University of Western Australia, 25 Stirling Hwy, Crawley, Western Australia 6009, Australia.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital, Tampere 33521, Finland.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, 751 85, Sweden.
Alan L JamesBusselton Population Medical Research Institute, Nedlands, Western Australia 6009, Australia.
John-Olov JanssonDepartment of Physiology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment &Health, School of Public Health, Imperial College London, UK.
Min A JhunDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Marit E JørgensenSteno Diabetes Center, Gentofte, Denmark.
Markus JuonalaDepartment of Medicine, University of Turku, Turku 20520 Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
Magnus KarlssonClinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden.
Heikki A KoistinenDepartment of Health, National Institute for Health and Welfare, Helsinki, FI-00271 Finland.ORCID 0000-0001-7870-070X
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Croatia.
Genovefa KolovouDepartment of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle Washington USA.
Bernhard K KrämerVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Kirsti KvaløyHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Timo A LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Lenore J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Karin LeanderUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Nanette R LeeUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Allan LinnebergResearch Centre for Prevention and Health, the Capital Region of Denmark, Copenhagen, Denmark.ORCID 0000-0002-0994-0184
Stephane LobbensUniversity of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID, Lille, France.
Marie LohDept Epidemiology and Biostatistics, School of Public Health, Imperical College London, UK.
Mattias LorentzonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Robert LubenDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5088-6343
Gitta LubkeDepartment of Psychology, University of Notre Dame, Notre Dame, USA.
Anja Ludolph-DonislawskiInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Sara LupoliDepartment of Health Sciences, University of Milan,Via A. Di Rudiní, 8 20142, Milano, Italy.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Reija MännikköKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne university hospital (CHUV), Lausanne, Switzerland.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Colin A McKenzieTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, JMAAW15 Jamaica.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Dan MellströmCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Grant W MontgomeryMolecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Aw Bill MuskBusselton Population Medical Research Institute, Nedlands, Western Australia 6009, Australia.
Narisu NarisuMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.ORCID 0000-0001-5047-4077
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Matthias OldenDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Sandosh PadmanabhanGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, Scotland.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Charlotta PisingerResearch Center for Prevention and Health, Glostrup Hospital, Glostrup Denmark.
David J PorteousGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, Scotland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Rajesh RawalResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Treva RiceDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts USA.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts USA.
Stephanie A BienDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle Washington USA.
Igor RudanUsher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Scotland, UK.ORCID 0000-0001-6993-6884
Serena SannaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, 09042, Monserrato, Italy.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK.
Kai SavonenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
David SchlessingerLaboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Salome ScholtensDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Claudia SchurmannThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0003-4158-9192
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Bengt SennbladCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Marten A SiemelinkLaboratory of Experimental Cardiology, Department of Cardiology, Division Heart &Lungs, UMC Utrecht, The Netherlands.
Günther SilbernagelDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Austria.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Jan A StaessenResearch Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Science , University of Leuven, Campus Sint Rafael, Kapucijnenvoer 35, Leuven; Belgium.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, UK.
Morris A SwertzDepartment of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Kent D TaylorCenter for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, California, USA.
Bamidele O TayoDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA.
Barbara ThorandInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Dorothee ThuillierUniversity of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID, Lille, France.
Jaakko TuomilehtoResearch Division, Dasman Diabetes Institute, Dasman, Kuwait.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Liesbeth VandenputCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Université Laval, Québec, Canada.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Germany.
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Gérard WaeberDepartment of Medicine, Internal Medicine, Lausanne university hospital (CHUV), Lausanne, Switzerland.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
R G J WestendorpDepartment of Public Health, and Center for Healthy Ageing, University of Copenhagen, Denmark.
Sarah WildUsher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Scotland, UK.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Bruce H R WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, 33 Bedford Place, London, WC1B 5JU, UK.ORCID 0000-0003-2079-4779
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
M Carola ZillikensDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Damiano BaldassarreDipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.ORCID 0000-0002-2766-8882
Beverley BalkauInserm U-1018, CESP, 94807 Villejuif cedex France.
Stefania BandinelliGeriatric Unit, Azienda USL Toscana centro, Florence Italy.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Marcel BruinenbergLifelines Cohort Study, PO Box 30001, 9700 RB Groningen, The Netherlands.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts USA.
Yii-DerIda ChenInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor-UCLA, Torrance, California 90502, USA.
Peter S ChinesMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Richard S CooperDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, 09042, Monserrato, Italy.
Daniele CusiSanipedia srl, Bresso (Milano), Italy and Institute of Biomedical Technologies National Centre of Research Segrate, Milano, Italy.
Ulf de FaireUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore Maryland, USA.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, SE-205 02 Malmö, Sweden.
Philippe FroguelUniversity of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID, Lille, France.
Penny Gordon-LarsenDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-5322-4188
Hans-Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Christopher A HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, 90089, USA.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Kristian HveemHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Andrew D JohnsonPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, USA.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, The Netherlands.ORCID 0000-0002-3246-8359
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Mika KivimakiDepartment of Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.ORCID 0000-0002-4699-5627
Jaspal S KoonerFaculty of Med, National Heart &Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Hammersmith Campus, Imperial College London, UK.
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, 33 Bedford Place, London, WC1B 5JU, UK.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
Winfried MärzSynlab Academy, Synlab Services GmbH, Mannheim, Germany.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Lyle J PalmerSchool of Public Health, University of Adelaide, Adelaide, South Australia, Australia.
Gerard PasterkampLaboratory of Experimental Cardiology, Department of Cardiology, Division Heart &Lungs, UMC Utrecht, The Netherlands.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle Washington USA.
Ozren PolasekUsher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Scotland, UK.
Bruce M PsatyDepartment of Medicine, University of Washington, Seattle, Washington 98195, USA.
Lu QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Blair H SmithGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0002-5362-9430
Thorkild I A SørensenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Henning TiemeierDepartment of Psychiatry Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-4395-1397
Elena TremoliDipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands.
Henrik VestergaardThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3090-269X
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne university hospital (CHUV), Lausanne, Switzerland.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
John B WhitfieldGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0001-5751-9178
Jessica TyrrellGenetics of Complex Traits, University of Exeter Medical School, RILD Building University of Exeter, Exeter, EX2 5DW, UK.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Inês BarrosoWellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Panagiotis DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Caroline S FoxNHLBI Framingham Heart Study, Framingham, Massachusetts, 01702 USA.
Joel N HirschhornDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston Massachusetts 02115, USA.
David J HunterDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
David P StrachanPopulation Health Research Institute, St. George's, University of London, London, SW17 0RE, UK.ORCID 0000-0001-7854-1366
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3015GE, The Netherlands.
Iris M HeidDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-6721-153X
Jonathan MarchiniDepartment of Statistics, University of Oxford, Oxford, UK.ORCID 0000-0003-0610-8322
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
Tuomas O KilpeläinenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.ORCID 0000-0002-0703-0742
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine; St. Louis, Missouri, 63108 USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
British Heart Foundation RG/10/12/28456British Heart Foundation RG/14/5/30893FIC NIH HHS R01 TW005596FIC NIH HHS R01 TW008288Intramural NIH HHS Z01 HG000024Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G0701863Medical Research Council G1001799Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12019/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2NCATS NIH HHS KL2 TR001109NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001881NCI NIH HHS P01 CA033619NCI NIH HHS R01 CA047988NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA136792NCI NIH HHS UM1 CA182913NCRR NIH HHS P20 RR020649NCRR NIH HHS UL1 RR025005NEI NIH HHS T32 EY022303NHGRI NIH HHS N01 HG065403NHGRI NIH HHS R01 HG002651NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG007376NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K99 HL130580NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL053353NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL126024NHLBI NIH HHS T32 HL007055NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL084729NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U10 HL054457NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA014041NIA NIH HHS HHSN271201100004CNIA NIH HHS N01 AG012100NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG023629NIA NIH HHS R03 AG046389NIA NIH HHS R37 AG013196NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD057194NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA018673NIDA NIH HHS R56 DA012854NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK078150NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK100383NIDDK NIH HHS U01 DK062418NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616NIEHS NIH HHS P30 ES010126NIGMS NIH HHS T32 GM074905NIH HHS S10 OD018522NIH HHS S10 OD020069NIMHD NIH HHS R01 MD009164NIMH NIH HHS R01 MH066206NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS U24 MH068457NLM NIH HHS R01 LM010098Wellcome TrustWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

Indexed as

AdiposityAdultBody Fat DistributionBody Mass IndexEpistasis, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansObesityPhenotypePolymorphism, Single NucleotideQuantitative Trait LociSmokingWaist CircumferenceWaist-Hip Ratio

Identifiers

PMID28443625
PMCPMC5414044

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