Evidence map›Paper›PMID 28443576›Full record

ArticleBalkan medical journal2017

Changes in Bacterial Resistance Patterns of Pediatric Urinary Tract Infections and Rationale for Empirical Antibiotic Therapy.

İbrahim Gökçe, Neslihan Çiçek, Serçin Güven, Ülger Altuntaş, Neşe Bıyıklı, Nurdan Yıldız, Harika Alpay

Open access · diamondAbstract read
In one paragraph

Article in Balkan medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

İbrahim GökçeDepartment of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.
Neslihan ÇiçekDepartment of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.
Serçin GüvenDepartment of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.
Ülger AltuntaşDepartment of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.
Neşe BıyıklıDepartment of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.
Nurdan YıldızDepartment of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.
Harika AlpayDepartment of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.
Marmara University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe causative agent spectrum and resistance patterns of urinary tract infections in children are affected by many factors.

aimsTo demonstrate antibiotic resistance in urinary tract infections and changing ratio in antibiotic resistance by years. STUDY

designRetrospective cross-sectional study.

methodsWe analysed antibiotic resistance patterns of isolated Gram (-) bacteria during the years 2011-2014 (study period 2) in children with urinary tract infections. We compared these findings with data collected in the same centre in 2001-2003 (study period 1).

resultsFour hundred and sixty-five uncomplicated community-acquired Gram (-) urinary tract infections were analysed from 2001-2003 and 400 from 2011-2014. Sixty-one percent of patients were female (1.5 girls : 1 boy). The mean age of children included in the study was 3 years and 9 months. Escherichia coli was the predominant bacteria isolated during both periods of the study (60% in study period 1 and 73% in study period 2). Bacteria other than E. coli demonstrated a higher level of resistance to all of the antimicrobials except trimethoprim-sulfamethoxazole than E. coli bacteria during the years 2011-2014. In our study, we found increasing resistance trends of urinary pathogens for cefixime (from 1% to 15%, p<0.05), amikacin (from 0% to 4%, p<0.05) and ciprofloxacin (from 0% to 3%, p<0.05) between the two periods. Urinary pathogens showed a decreasing trend for nitrofurantoin (from 17% to 7%, p=0.0001). No significant trends were detected for ampicillin (from 69% to 71%), amoxicillin-clavulanate (from 44% to 43%), cefazolin (from 39% to 32%), trimethoprim-sulfamethoxazole (from 32% to 31%), cefuroxime (from 21% to 18%) and ceftriaxone (from 10% to 14%) between the two periods (p>0.05).

conclusionIn childhood urinary tract infections, antibiotic resistance should be evaluated periodically and empiric antimicrobial therapy should be decided according to antibiotic sensitivity results.

Indexed as

AdolescentAmoxicillin-Potassium Clavulanate CombinationAmpicillinAnti-Bacterial AgentsBenzenesulfonamidesCefazolinCefiximeCeftriaxoneCefuroximeChildChild, PreschoolCiprofloxacinCommunity-Acquired InfectionsCross-Sectional StudiesDrug CombinationsDrug Resistance, BacterialAmoxicillin-Potassium Clavulanate CombinationAmpicillinAnti-Bacterial AgentsBenzenesulfonamidesCefazolinCefiximeCeftriaxoneCefuroximeCiprofloxacinDrug CombinationsSulfamethizoleTrimethoprimtrimethoprim sulfamethizoleantibiotic resistance children.Urinary tract infection

Identifiers

PMID28443576
PMCPMC5635630
OpenAlexW2603709550

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.