ArticleReproductive sciences (Thousand Oaks, Calif.)2018
Adverse Placental Perfusion and Pregnancy Outcomes in a New Nonhuman Primate Model of Gestational Protein Restriction.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Comparison of Laser Doppler Flowmetry With Contrast-Enhanced Ultrasound to Approximate Placental Microvascular Blood Flow in the African Green Monkey (Chlorocebus aethiops sabaeus).Journal of medical primatology · 2026Article
- Application of Chorionic Villus Sampling to Longitudinal Studies in Pregnant Non-Human Primate Models.Animals : an open access journal from MDPI · 2026Article
- Article
- Contrast-enhanced ultrasound in pregnancy.Abdominal radiology (New York) · 2025Review
- Safety of contrast-enhanced ultrasound using microbubbles in human pregnancy: A scoping review.Ultraschall in der Medizin (Stuttgart, Germany : 1980) · 2025Article
- Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Gestational and early postnatal protein malnutrition disrupts neurodevelopment in rhesus macaques.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- B-Flow/Spatiotemporal Image Correlation M-Mode and Contrast-Enhanced/Microbubble Ultrasonography Quantification of Spiral Artery Distensibility and Placental Intervillous Perfusion in the First Trimester in a Primate Model of Impaired Spiral Artery Remodeling.Ultrasound in medicine & biology · 2023Article
- Ultrasound evaluation of normal rhesus macaque fetal biometry and uteroplacental hemodynamics.American journal of primatology · 2023Article
- Impaired placental hemodynamics and function in a non-human primate model of gestational protein restriction.Scientific reports · 2023Article
- Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model.Scientific reports · 2022Article
- The Influence of Diet on Metabolism and Health Across the Lifespan in Nonhuman Primates.Current opinion in endocrine and metabolic research · 2022Article
- Placental adaptations in a nonhuman primate model of gestational protein restriction.Journal of developmental origins of health and disease · 2021Article
- The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero†.Biology of reproduction · 2021Review
- Contrast-enhanced ultrasound for the assessment of placental development and function.BioTechniques · 2020Review
- Effects of pre- and postnatal protein restriction on maternal and offspring metabolism in the nonhuman primate.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation.NeuroImage · 2020Article
- Amino Acids in Reproductive Nutrition and Health.Advances in experimental medicine and biology · 2020Review
- Micro-anatomic alterations of the placenta in a non-human primate model of gestational protein-restriction.PloS one · 2020Article
- Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate.Endocrinology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Maternal malnutrition during pregnancy impacts fetal growth, with developmental consequences that extend to later life outcomes. In underdeveloped countries, this malnutrition typically takes the form of poor dietary protein content and quality, even if adequate calories are consumed. Here, we report the establishment of a nonhuman primate model of gestational protein restriction (PR) in order to understand how placental function and pregnancy outcomes are affected by protein deficiency. Rhesus macaques were assigned to either a control diet containing 26% protein or switched to a 13% PR diet prior to conception and maintained on this PR diet throughout pregnancy. Standard fetal biometry, Doppler ultrasound of uteroplacental blood flow, ultrasound-guided amniocentesis, and contrast-enhanced ultrasound (CE-US) to assess placental perfusion were performed mid-gestation (gestational day 85 [G85] where term is G168) and in the early third trimester (G135). Our data demonstrate that a 50% reduction in dietary protein throughout gestation results in reduced placental perfusion, fetal growth restriction, and a 50% rate of pregnancy loss. In addition, we demonstrate reduced total protein content and evidence of fetal hypoxia in the amniotic fluid. This report highlights the use of CE-US for in vivo assessment of placental vascular function. The ability to detect placental dysfunction, and thus a compromised pregnancy, early in gestation, may facilitate the development of interventional strategies to optimize clinical care and improve long-term offspring outcomes, which are future areas of study in this new model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.