Evidence map›Paper›PMID 28443329›Full record

ArticleJournal of the American Chemical Society2017

Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange.

Johannes F P Colell, Meike Emondts, Angus W J Logan, Kun Shen, Junu Bae, Roman V Shchepin, Gerardo X Ortiz, Peter Spannring, Qiu Wang, Steven J Malcolmson and 6 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. HyperpolarizedACS sensors · 2026
    Article
  3. The journal of physical chemistry. B · 2025
    Article
  4. Article
  5. Article
  6. The journal of physical chemistry letters · 2024
    Article
  7. Article
  8. Reversible Parahydrogen Induced Hyperpolarization ofAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-Chemphyschem : a European journal of chemical physics and physical chemistry · 2023
    Article
  14. Article
  15. Article
  16. Design, synthesis and evaluation ofBioorganic & medicinal chemistry · 2022
    Article
  17. RapidAnalytical chemistry · 2022
    Article
  18. Analysis of Complex Mixtures by Chemosensing NMR UsingAccounts of chemical research · 2022
    Article
  19. SABRE hyperpolarized anticancer agents for use inMagnetic resonance in medicine · 2022
    Article
  20. Chemical science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Johannes F P ColellDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.ORCID 0000-0001-9020-344X
Meike EmondtsInstitute for Technical and Macromolecular Chemistry, RWTH Aachen University , Worringerweg 2, 52072 Aachen, Germany.
Angus W J LoganDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.
Kun ShenDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.
Junu BaeDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.
Roman V ShchepinDepartments of Radiology and Radiological Sciences, Biomedical Engineering, Physics and Astronomy, Vanderbilt Institute of Imaging Science (VUIIS), Vanderbilt Ingram Cancer Center (VICC), Vanderbilt University , Nashville, Tennessee 37232, United States.
Gerardo X OrtizDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.
Peter SpannringInstitute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Qiu WangDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.ORCID 0000-0002-6803-9556
Steven J MalcolmsonDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.ORCID 0000-0003-3229-0949
Eduard Y ChekmenevDepartments of Radiology and Radiological Sciences, Biomedical Engineering, Physics and Astronomy, Vanderbilt Institute of Imaging Science (VUIIS), Vanderbilt Ingram Cancer Center (VICC), Vanderbilt University , Nashville, Tennessee 37232, United States.ORCID 0000-0002-8745-8801
Martin C FeitersInstitute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Floris P J T RutjesInstitute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.ORCID 0000-0003-1538-3852
Bernhard BlümichInstitute for Technical and Macromolecular Chemistry, RWTH Aachen University , Worringerweg 2, 52072 Aachen, Germany.
Thomas TheisDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.ORCID 0000-0001-6779-9978
Warren S WarrenDepartment of Chemistry, Duke University , Durham, North Carolina 27708, United States.

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB020323 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2015 to 2016
$416k
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB018014 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2014 to 2015
$407k
NIBIB NIH HHS P41 EB015897NIBIB NIH HHS R21 EB018014NIBIB NIH HHS R21 EB020323
6 · The paper itself

Abstract

Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization source. However, current SABRE faces a number of stumbling blocks for translation to biochemical and clinical settings. Difficulties include inefficient polarization in water, relatively short-lived

Indexed as

HydrogenMagnetic Resonance SpectroscopyMolecular StructureNitrogen IsotopesWaterHydrogenNitrogen-15Nitrogen IsotopesWater

Identifiers

PMID28443329
PMCPMC5578426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.