Evidence map›Paper›PMID 28443246›Full record

ArticleFrontiers in cellular and infection microbiology2017

Genetic and Dietary Iron Overload Differentially Affect the Course of

Manfred Nairz, Andrea Schroll, David Haschka, Stefanie Dichtl, Piotr Tymoszuk, Egon Demetz, Patrizia Moser, Hubertus Haas, Ferric C Fang, Igor Theurl and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Exploiting haem-iron dependence of nontypeableFrontiers in cellular and infection microbiology · 2025
    Review
  5. Iron, Hepcidin, and Immunity.Advances in experimental medicine and biology · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Cell-specific expression ofHaematologica · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Metabolic reprogramming ofMicrobial cell (Graz, Austria) · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Manfred NairzDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
Andrea SchrollDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
David HaschkaDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
Stefanie DichtlDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
Piotr TymoszukDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
Egon DemetzDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
Patrizia MoserDepartment of Pathology, Medical University of InnsbruckInnsbruck, Austria.
Hubertus HaasDivision of Molecular Microbiology, Biocenter, Medical University of InnsbruckInnsbruck, Austria.
Ferric C FangDepartment of Laboratory Medicine, University of WashingtonSeattle, WA, USA.
Igor TheurlDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
Günter WeissDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of InnsbruckInnsbruck, Austria.
Universität Innsbruck · ATInnsbruck Medical University · ATUniversity of Washington · US

Funding

Typhoid Pathogenesis and ImmunityR01AI112640 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2015 to 2019
$2.1M
Antimicrobial Actions of Nitric OxideR01AI118962 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2016 to 2020
$1.9M
Austrian Science Fund FWF W 1253NIAID NIH HHS R01 AI112640NIAID NIH HHS R01 AI118962
6 · The paper itself

Abstract

Genetic and dietary forms of iron overload have distinctive clinical and pathophysiological features. HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. In contrast, excessive dietary iron intake results in iron deposition in macrophages. However, the functional consequences of genetic and dietary iron overload for the control of microbes are incompletely understood. Using

Indexed as

Host-Pathogen InteractionsAnimalsDisease Models, AnimalHemochromatosis ProteinIron, DietaryIron OverloadMiceMice, KnockoutSalmonella InfectionsSalmonella typhimuriumHemochromatosis ProteinHfe protein, mouseIron, DietaryhepcidininfectionironlipocalinmacrophageSalmonellasiderophore

Identifiers

PMID28443246
PMCPMC5387078
OpenAlexW2606065039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.