Evidence map›Paper›PMID 28443200›Full record

ArticleCancer biology & medicine2017

Epidemiology of ovarian cancer: a review.

Brett M Reid, Jennifer B Permuth, Thomas A Sellers

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Cancer biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 803 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
803citing papers in PubMed, 5 pooled it
138.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04812938 unknown statusnot on this mapstarted 2021, after this paper: background citation

Exploiting Pathogenic Tp53 Mutation for Early Diagnosis of Ovarian Cancer by Mean of Papanicolau Test

TypeobservationalSponsorAzienda Ospedaliera San Giovanni BattistaRan2021 to 2022Enrolled190ConditionsOvarian CancerArmsPatients with Ovarian cancer and pap test available
NCT05251883 recruitingnot on this mapstarted 2022, after this paper: background citation

A Study to Analyze Data on Metastatic Ovarian Cancer Using Multi-omics

Typeobservational_patient_registrySponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2022 to 2026Enrolled200ConditionsOvarian Cancer
NCT06253559 completednot on this map

Clinical and Pathological Characteristics of Women With Ovarian Cancers, A National, Retrospective Cross-Sectional Study in Syria During the War

TypeobservationalSponsorLatakia UniversityRan2017 to 2023Enrolled531ConditionsOvarian Cancer
3 · Its place in the literature

Who cites it

803 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,542 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Trial
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  8. Article
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  10. Review
  11. A Multistate Survival Model to Identify Risk Factors for Lethal Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Mechanistic insights into HAGLROS-mediated therapy resistance in ovarian cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  19. Article
  20. Breast cancer prevention in patients with gBRCA-mutated ovarian cancer.Journal of cancer research and clinical oncology · 2026
    Article

743 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brett M ReidDepartment of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa 33612, FL, USA.
Jennifer B PermuthDepartment of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa 33612, FL, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa 33612, FL, USA.
Moffitt Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world and the tenth most common in China. Epithelial OC is the most predominant pathologic subtype, with five major histotypes that differ in origination, pathogenesis, molecular alterations, risk factors, and prognosis. Genetic susceptibility is manifested by rare inherited mutations with high to moderate penetrance. Genome-wide association studies have additionally identified 29 common susceptibility alleles for OC, including 14 subtype-specific alleles. Several reproductive and hormonal factors may lower risk, including parity, oral contraceptive use, and lactation, while others such as older age at menopause and hormone replacement therapy confer increased risks. These associations differ by histotype, especially for mucinous OC, likely reflecting differences in etiology. Endometrioid and clear cell OC share a similar, unique pattern of associations with increased risks among women with endometriosis and decreased risks associated with tubal ligation. OC risks associated with other gynecological conditions and procedures, such as hysterectomy, pelvic inflammatory disease, and polycystic ovarian syndrome, are less clear. Other possible risk factors include environmental and lifestyle factors such as asbestos and talc powder exposures, and cigarette smoking. The epidemiology provides clues on etiology, primary prevention, early detection, and possibly even therapeutic strategies.

Indexed as

epidemiologyhistologyOvarian cancerreproductive historyrisk factors

Identifiers

PMID28443200
PMCPMC5365187
OpenAlexW2594404528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.