ArticleFrontiers in microbiology2017
Inbred Mouse Populations Exhibit Intergenerational Changes in Intestinal Microbiota Composition and Function Following Introduction to a Facility.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Breaking down barriers: is intestinal mucus degradation byInfection and immunity · 2025Review
- The host genotype actively shapes its microbiome across generations in laboratory mice.Microbiome · 2024Article
- Causal relationship between gut microbiota with subcutaneous and visceral adipose tissue: a bidirectional two-sample Mendelian Randomization study.Frontiers in microbiology · 2023Article
- Effect of Husbandry Practices on the Fecal Microbiota of C57BL/6J Breeding Colonies Housed in 2 Different Barrier Facilities in the Same Institution.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Cage and maternal effects on the bacterial communities of the murine gut.Scientific reports · 2021Article
- Establishment of murine gut microbiota in gnotobiotic mice.iScience · 2021Article
- A High Amylose Wheat Diet Improves Gastrointestinal Health Parameters and Gut Microbiota in Male and Female Mice.Foods (Basel, Switzerland) · 2021Article
- Supplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats.Applied microbiology and biotechnology · 2021Article
- PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Outbreaks of Typhlocolitis Caused by Hypervirulent Group ST1Comparative medicine · 2020Article
- Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome.Nutrients · 2020Article
- Facility-dependent metabolic phenotype and gut bacterial composition in CD-1 mice from a single vendor: A brief report.PloS one · 2020Article
- Review
- Microbe and host interaction in gastrointestinal homeostasis.Psychopharmacology · 2019Article
- The Formation of Glycan-Specific Natural Antibodies Repertoire in GalT-KO Mice Is Determined by Gut Microbiota.Frontiers in immunology · 2019Article
- Effects of Fenbendazole-impregnated Feed and Topical Moxidectin during Quarantine on the Gut Microbiota of C57BL/6 Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome.PeerJ · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inbred mice are used to investigate many aspects of human physiology, including susceptibility to disease and response to therapies. Despite increasing evidence that the composition and function of the murine intestinal microbiota can substantially influence a broad range of experimental outcomes, relatively little is known about microbiome dynamics within experimental mouse populations. We investigated changes in the intestinal microbiome between C57BL/6J mice spanning six generations (assessed at generations 1, 2, 3, and 6), following their introduction to a stringently controlled facility. Fecal microbiota composition and function were assessed by 16S rRNA gene amplicon sequencing and liquid chromatography mass spectrometry, respectively. Significant divergence of the intestinal microbiota between founder and second generation mice, as well as continuing inter-generational variance, was observed. Bacterial taxa whose relative abundance changed significantly through time included
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Registered trials
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