ReviewFrontiers in neuroanatomy2017
Roles of Multiple Globus Pallidus Territories of Monkeys and Humans in Motivation, Cognition and Action: An Anatomical, Physiological and Pathophysiological Review.
Review in Frontiers in neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Aberrant functional connectivity of the globus pallidus in the modulation of the relationship between childhood trauma and major depressive disorder.Journal of psychiatry & neuroscience : JPNTrial
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- A multi-modal parcellation of human globus pallidus and its implications for symptom prediction and stratification in Parkinson's disease.BMC medicine · 2026Article
- Genoarchitecture and input-output organization of the mouse basal ganglia and thalamic parafascicular nucleus.Nature neuroscience · 2026Article
- Pallidal beta power is associated with depression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates.Current biology : CB · 2025Article
- Parameterization of intraoperative human microelectrode recordings: Linking action potential morphology to brain anatomy.bioRxiv : the preprint server for biology · 2025Article
- Parameterization of intraoperative human microelectrode recordings: Linking action potential morphology to brain anatomy.PLoS computational biology · 2025Article
- Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets.Science advances · 2025Article
- Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline.Neuroprotection (Chichester, England) · 2025Review
- GPe Projections to the Retrorubral Field Give Rise to Diverging GABAergic and DAergic Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Randomized prenatal and postnatal nutrient supplementation shows no long-term impact on cortical gray matter in Ghanaian children.Frontiers in human neuroscience · 2025Article
- The role of pallidal substance P and neurokinin receptors in the consolidation of spatial memory of rats.The international journal of neuropsychopharmacology · 2024Article
- Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.Developmental cognitive neuroscience · 2024Article
- Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study.Heliyon · 2024Article
- Pramipexole Hyperactivates the External Globus Pallidus and Impairs Decision-Making in a Mouse Model of Parkinson's Disease.International journal of molecular sciences · 2024Article
- Diagnostic and predictive power of plasma proteins in Alzheimer's disease: a cross-sectional and longitudinal study in China.Scientific reports · 2024Article
- Distinct basal ganglia contributions to learning from implicit and explicit value signals in perceptual decision-making.Nature communications · 2024Article
- Inverse pattern of GABAergic system impairment in the external versus internal globus pallidus in male heroin addicts.European archives of psychiatry and clinical neuroscience · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The globus pallidus (GP) communicates with widespread cortical areas that support various functions, including motivation, cognition and action. Anatomical tract-tracing studies revealed that the anteroventral GP communicates with the medial prefrontal and orbitofrontal cortices, which are involved in motivational control; the anterodorsal GP communicates with the lateral prefrontal cortex, which is involved in cognitive control; and the posterior GP communicates with the frontal motor cortex, which is involved in action control. This organization suggests that distinct subdivisions within the GP play specific roles. Neurophysiological studies examining GP neurons in monkeys during behavior revealed that the types of information coding performed within these subdivisions differ greatly. The anteroventral GP is characterized by activities related to motivation, such as reward seeking and aversive avoidance; the anterodorsal GP is characterized by activity that reflects cognition, such as goal decision and action selection; and the posterior GP is characterized by activity associated with action preparation and execution. Pathophysiological studies have shown that GABA-related substances or GP lesions result in abnormal activity in the GP, which causes site-specific behavioral and motor symptoms. The present review article discusses the anatomical organization, physiology and pathophysiology of the three major GP territories in nonhuman primates and humans.
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