Evidence map›Paper›PMID 28442993›Full record

ArticleFrontiers in molecular neuroscience2017

Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP.

Alfredo Ghezzi, Xiaolei Li, Linda K Lew, Thilini P Wijesekera, Nigel S Atkinson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. AlteredeNeuro · 2026
    Article
  2. AlteredbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  7. Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022
    Article
  8. Article
  9. Transcriptional Correlates of Chronic Alcohol Neuroadaptation inFrontiers in behavioral neuroscience · 2021
    Article
  10. Article
  11. Article
  12. Flying Together:International journal of molecular sciences · 2020
    Review
  13. Insights from intoxicated Drosophila.Alcohol (Fayetteville, N.Y.) · 2019
    Review
  14. Epigenetic Mechanisms of Alcohol Neuroadaptation: Insights fromJournal of experimental neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Alfredo GhezziDepartment of Biology, University of Puerto Rico, Río Piedras CampusSan Juan, Puerto Rico.
Xiaolei LiDepartment of Neuroscience and Waggoner Center for Alcohol and Addiction Research, The University of Texas at AustinAustin, TX, USA.
Linda K LewDepartment of Neuroscience and Waggoner Center for Alcohol and Addiction Research, The University of Texas at AustinAustin, TX, USA.
Thilini P WijesekeraDepartment of Neuroscience and Waggoner Center for Alcohol and Addiction Research, The University of Texas at AustinAustin, TX, USA.
Nigel S AtkinsonDepartment of Neuroscience and Waggoner Center for Alcohol and Addiction Research, The University of Texas at AustinAustin, TX, USA.
The University of Texas at Austin · USUniversity of Puerto Rico at Río Piedras · PR

Funding

Epigenetic modification as a mechanism to produce functional toleranceR01AA018037 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI ATKINSON, NIGEL S · 2008 to 2018
$3.3M
NIAAA NIH HHS R01 AA018037
6 · The paper itself

Abstract

Homeostatic neural adaptations to alcohol underlie the production of alcohol tolerance and the associated symptoms of withdrawal. These adaptations have been shown to persist for relatively long periods of time and are believed to be of central importance in promoting the addictive state. In

Indexed as

addictionalcohol tolerancechromatin remodelingCREB-binding proteinDrosophilasynaptic homeostasis

Identifiers

PMID28442993
PMCPMC5387060
OpenAlexW2606257937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.