Innate and adaptive immunity shape circulating HCV strains.

Silvana Gaudieri, Michaela Lucas

Abstract readNews

In one paragraph

Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 94% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Silvana GaudieriSchool of Human Sciences, University of Western Australia, Perth, Western Australia, Australia, the Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA, and the Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.

Michaela LucasInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia, the School of Medicine and Pharmacology, Harry Perkins Institute, University of Western Australia, Perth, Western Australia, Australia, and the School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.

Murdoch University · AUUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An unbiased genome-to-genome analysis in chronic hepatitis C virus (HCV) infection confirms the innate and adaptive arms of the immune system as drivers of viral evolution. Viral adaptation has a critical role in the interaction between host and pathogen and has important clinical implications for infection outcome.

Indexed as

Adaptive ImmunityHepacivirusHepatitis CHost-Pathogen InteractionsHumansImmunity, Innate

Identifiers

PMID28442794

DOI10.1038/ng.3856

OpenAlexW2608654245

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.