ArticleScientific reports2017
As a carrier-transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Baseline Neutrophil-to-Lymphocyte Ratio Stratifies Early Trichoscopic Response to Platelet-Rich Plasma-Based Regimens in Non-Scarring Alopecia: A Real-World Cohort with Internal Validation Using an Interpretable Neural Network.Life (Basel, Switzerland) · 2026Article
- Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration.International journal of extreme manufacturing · 2025Review
- Understanding the cellular dynamics, engineering perspectives and translation prospects in bioprinting epithelial tissues.Bioactive materials · 2025Review
- Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome.Cells · 2024Review
- Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery.Pharmaceutics · 2024Review
- Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway.Journal of nanobiotechnology · 2024Article
- In vitro induction of hair follicle signatures using human dermal papilla cells encapsulated in fibrin microgels.Cell proliferation · 2024Article
- JAM-A facilitates hair follicle regeneration in alopecia areata through functioning as ceRNA to protect VCAN expression in dermal papilla cells.Precision clinical medicine · 2022Article
- Regeneration Through Platelet Rich Plasma - A Cell Therapy with a Path Full of Milestones, Controversies and Cautions!Indian dermatology online journal · 2021Article
- Preparation of Platelet-Rich Plasma: National IADVL PRP Taskforce Recommendations.Indian dermatology online journal · 2021Review
- Platelet-Rich Plasma in Androgenetic Alopecia.Indian dermatology online journal · 2021Article
- [Research advances on autologous hair transplantation in the treatment of secondary cicatricail alopecia].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- Comparative study of the therapeutic efficacy of autologous platelet-rich plasma and honey in healing skin wounds in sheep.Veterinary world · 2021Article
- HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cellsMolecular medicine reports · 2021Article
- Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration.Materials today. Bio · 2021Review
- Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis.Frontiers in cell and developmental biology · 2021Review
- Article
- Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?Stem cells translational medicine · 2020Article
- Platelet sonicates activate hair follicle stem cells and mediate enhanced hair follicle regeneration.Journal of cellular and molecular medicine · 2020Article
- A Novel and Convenient Method for the Preparation and Activation of PRP without Any Additives: Temperature Controlled PRP.BioMed research international · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis of hair follicles during development and in hair reconstitution assays involves complex interactions between epithelial cells and dermal papilla cells (DPCs). DPCs may be a source of cells for hair regeneration in alopecia patients. Reconstitution of engineered hair follicles requires in vitro culture of trichogenic cells, a three-dimensional scaffolds, and biomolecular signals. However, DPCs tend to lose their biological activity when cultured as trichogenic cells, and scaffolds currently used for hair follicle regeneration lack biological efficiency and biocompatibility. Platelet-rich plasma (PRP) gel forms a three-dimensional scaffold that can release endogenous growth factors, is mitogenic for a variety of cell types and is used in model tissue repair and regeneration systems. We found that 5% activated PRP significantly enhanced cell proliferation and hair-inductive capability of mouse and human DPCs in vitro and promoted mouse hair follicle formation in vivo. PRP also formed a three-dimensional gel after activation. We used PRP gel as a scaffold to form many de novo hair follicles on a plane surface, showing it to be candidate bioactive scaffold capable of releasing endogenous growth factors for cell-based hair follicle regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.