ArticleScientific reports2016
Generation of mutation hotspots in ageing bacterial colonies.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Biological Systems as Physical Data Processors: Evolution as a Case of Embodied Computing.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Single-Cell Membrane-Permeabilization Kinetics Reveal Species-Specific Responses to Antimicrobial Photodynamic Treatment.ACS omega · 2026Article
- A Short-Term View of Protein Sequence Evolution from Salmonella.Genome biology and evolution · 2025Article
- Diversity of Transcriptional Regulatory Adaptation in E. coli.Molecular biology and evolution · 2024Article
- Mutations upstream fromJournal of bacteriology · 2024Article
- cAMP Activation of the cAMP Receptor Protein, a Model Bacterial Transcription Factor.Journal of microbiology (Seoul, Korea) · 2023Review
- Tolerance and resistance of microbial biofilms.Nature reviews. Microbiology · 2022Review
- Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry.Microbial biotechnology · 2022Review
- In vivo, in vitro and in silico: an open space for the development of microbe-based applications of synthetic biology.Microbial biotechnology · 2022Article
- Article
- A mutational hotspot that determines highly repeatable evolution can be built and broken by silent genetic changes.Nature communications · 2021Article
- Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors.Nature communications · 2021Article
- Experimental evolution of extremophile resistance to ionizing radiation.Trends in genetics : TIG · 2021Review
- Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi.Metabolic engineering communications · 2020Article
- Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces.Life (Basel, Switzerland) · 2020Article
- Article
- Tolerance and Resistance ofFrontiers in microbiology · 2019Review
- Meta synthetic biology: controlling the evolution of engineered living systems.Microbial biotechnology · 2019Article
- Mutations in the Global Transcription Factor CRP/CAP: Insights from Experimental Evolution and Deep Sequencing.Computational and structural biotechnology journal · 2019Review
- Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How do ageing bacterial colonies generate adaptive mutants? Over a period of two months, we isolated on ageing colonies outgrowing mutants able to use a new carbon source, and sequenced their genomes. This allowed us to uncover exquisite details on the molecular mechanism behind their adaptation: most mutations were located in just a few hotspots in the genome, and over time, mutations increasingly were consistent with the involvement of 8-oxo-guanosine, formed exclusively on the transcribed strand. This work provides strong support for retromutagenesis as a general process creating adaptive mutations during ageing.
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