ArticleEmerging microbes & infections2017
Hepatitis A virus infections and outbreaks in asylum seekers arriving to Germany, September 2015 to March 2016.
Article in Emerging microbes & infections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Hepatitis A in the Eastern Mediterranean Region: a comprehensive review.Human vaccines & immunotherapeutics · 2022Pooled it
- A randomized controlled trial of comparative effectiveness between the 2 dose and 3 dose regimens of hepatitis a vaccine in kidney transplant recipients.Scientific reports · 2021Trial
- Infectious Diseases in the Context of the War in Ukraine: Refugee Health Implications in Romania.Healthcare (Basel, Switzerland) · 2025Article
- Unusual Surge of Acute Hepatitis A Cases in 2016 and 2017 in Malaga, Southern Spain: Characterization and Relationship with Other Concurrent European Outbreaks.Journal of clinical medicine · 2023Article
- Hepatitis A seroprevalence, vaccination status and demographic determinants in children and adolescents in Germany, 2014-2017, a population-based study.Scientific reports · 2023Article
- [Epidemiology of viral hepatitis A to E in Germany].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2022Review
- Resurgence of an international hepatitis A outbreak linked to imported frozen strawberries, Germany, 2018 to 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Implications of a change in case definition and screening of asylum seekers for hepatitis B surveillance in Germany in 2015 and 2016.Epidemiology and infection · 2020Article
- Epidemiology of hepatitis A in Greece in the last decade: management of reported cases and outbreaks and lessons learned.Epidemiology and infection · 2020Article
- Sequencing of the VP1-2A Genome Segment for Hepatitis A Subtyping.Sovremennye tekhnologii v meditsine · 2020Article
- Hepatitis A virus age-specific seroprevalence after the implementation of a Toddlers' Vaccination in Turkey: Shifting susceptibility to adolescents.Turk pediatri arsivi · 2020Article
- Infectious Diseases among Refugee Children.Children (Basel, Switzerland) · 2019Review
- Toward development of generic inhibitors against the 3C proteases of picornaviruses.The FEBS journal · 2019Article
- Children on the move in Europe: a narrative review of the evidence on the health risks, health needs and health policy for asylum seeking, refugee and undocumented children.BMJ paediatrics open · 2019Article
- Acute hepatitis A virus infection in patients hospitalized at the Department of Infectious Diseases, Medical University of Lublin (Eastern Poland) in 2017 - a hospital-based retrospective study.Clinical and experimental hepatology · 2018Article
- Hepatitis A virus infections, immunisations and demographic determinants in children and adolescents, Germany.Scientific reports · 2018Article
- Globalization and the Changing Epidemiology of Hepatitis A Virus.Cold Spring Harbor perspectives in medicine · 2018Review
- Travel-associated hepatitis A in Europe, 2009 to 2015.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From September 2015 to March 2016, hepatitis A notifications in Germany increased by 45% to 699 cases compared to 482 cases in the same period of the previous year. Children aged five to nine years were predominantly affected (22% of all cases in this period). We hypothesized that this increase could be explained by the marked influx of asylum seekers in this time period. We analysed national surveillance data and estimated the number of imported and autochthonous hepatitis A cases in asylum seekers. We also investigated molecular signatures of hepatitis A viruses sampled from asylum seekers to identify chains of transmission. We found that 40% (278 cases) of all 699 hepatitis A cases notified between September 2015 and March 2016 in Germany concerned asylum seekers. Most infections were acquired abroad, but at least 24% accounted for autochthonous infections. Among asylum seekers, children aged five to nine years were overrepresented with 97 of 278 (35%) notified cases. The analysed hepatitis A virus sequences were primarily subgenotype IB strains and clustered with previously isolated samples from the Middle East, Turkey, Pakistan and East Africa. Except one transmission from an asymptomatic child to a nursery nurse working in a mass accommodation, we are not aware of infection chains involving asylum seekers and German residents. We conclude that asylum-seeking children and adolescents are susceptible to hepatitis A virus infections, particularly children aged five to nine years. Measures to prevent secondary infections in asylum seekers such as extended hygiene measures and post-exposure prophylaxis seem advisable.
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