ArticleScientific reports2016
The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated "magic" RNA polymerase.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Functional Assessment of Orphan Proteins in theMicroorganisms · 2026Article
- Identification of the orange pigment in Nonomuraea gerenzanensis and development of a pigment-free mutant.AMB Express · 2025Article
- Rid7C, a Member of the YjgF/YER057c/UK114 (Rid) Protein Family, Is a Novel Endoribonuclease That Regulates the Expression of a Specialist RNA Polymerase Involved in Differentiation in Nonomuraea gerenzanensis.Journal of bacteriology · 2022Article
- Serendipity Reveals the Function and Physiological Role of a Large Family of Proteins.Journal of bacteriology · 2022Article
- Genomic Insights into the Distribution and Phylogeny of Glycopeptide Resistance Determinants within theAntibiotics (Basel, Switzerland) · 2021Article
- Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD.MicrobiologyOpen · 2021Article
- Interplay between Non-Coding RNA Transcription, Stringent/Relaxed Phenotype and Antibiotic Production inAntibiotics (Basel, Switzerland) · 2021Article
- Review
- Genomic-Led Discovery of a Novel Glycopeptide Antibiotic byACS chemical biology · 2021Article
- A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance.Scientific reports · 2020Article
- Glycopeptide Antibiotic Resistance Genes: Distribution and Function in the Producer Actinomycetes.Frontiers in microbiology · 2020Review
- New Molecular Tools for Regulation and Improvement of A40926 Glycopeptide Antibiotic Production inFrontiers in microbiology · 2020Article
- The gut microbiome of horses: current research on equine enteral microbiota and future perspectives.Animal microbiome · 2019Review
- Draft Genome Sequence ofMicrobiology resource announcements · 2019Article
- Specificity of Induction of Glycopeptide Antibiotic Resistance in the Producing Actinomycetes.Antibiotics (Basel, Switzerland) · 2018Article
- Complex Regulatory Networks Governing Production of the Glycopeptide A40926.Antibiotics (Basel, Switzerland) · 2018Review
- The High-Throughput Analyses Era: Are We Ready for the Data Struggle?High-throughput · 2018Article
- Human Microbiome Acquisition and Bioinformatic Challenges in Metagenomic Studies.International journal of molecular sciences · 2018Review
- A common microbial signature is present in the lower airways of interstitial lung diseases including sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to the widely accepted consensus of the existence of a single RNA polymerase in bacteria, several actinomycetes have been recently shown to possess two forms of RNA polymerases due the to co-existence of two rpoB paralogs in their genome. However, the biological significance of the rpoB duplication is obscure. In this study we have determined the genome sequence of the lipoglycopeptide antibiotic A40926 producer Nonomuraea gerenzanensis ATCC 39727, an actinomycete with a large genome and two rpoB genes, i.e. rpoB(S) (the wild-type gene) and rpoB(R) (the mutant-type gene). We next analyzed the transcriptional and metabolite profiles in the wild-type gene and in two derivative strains over-expressing either rpoB(R) or a mutated form of this gene to explore the physiological role and biotechnological potential of the "mutant-type" RNA polymerase. We show that rpoB(R) controls antibiotic production and a wide range of metabolic adaptive behaviors in response to environmental pH. This may give interesting perspectives also with regard to biotechnological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.