Evidence map›Paper›PMID 28442574›Full record

ArticleThe Journal of biological chemistry2017

The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2.

Goutham Pattabiraman, Rahul Panchal, Andrei E Medvedev

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Review
  3. Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Goutham PattabiramanFrom the Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030.
Rahul PanchalFrom the Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030.
Andrei E MedvedevFrom the Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030 medvedev@uchc.edu.ORCID 0000-0002-1276-1400
UConn Health · US

Funding

Mechanisms of Impaired Mycobacteria Sensing by TLR2 and TLR4 Polymorphic VariantsR56AI097210 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MEDVEDEV, ANDREI E · 2014 to 2014
$413k
NIAID NIH HHS R56 AI097210
6 · The paper itself

Abstract

Toll-like receptor 2 (TLR2) plays a critical role in host defenses against mycobacterial infections. The R753Q TLR2 polymorphism has been associated with increased incidence of tuberculosis and infections with non-tuberculous mycobacteria in human populations, but the mechanisms by which this polymorphism affects TLR2 signaling are unclear. In this study, we determined the impact of the R753Q TLR2 polymorphism on macrophage sensing of

Indexed as

Immunity, InnateMutation, MissensePolymorphism, GeneticAmino Acid SubstitutionAnimalsCytokinesExtracellular Signal-Regulated MAP KinasesHEK293 CellsHumansMacrophagesMAP Kinase Signaling SystemMiceMice, Mutant StrainsMycobacterium Infections, NontuberculousMycobacterium smegmatisMyeloid Differentiation Factor 88CytokinesExtracellular Signal-Regulated MAP KinasesMyd88 protein, mouseMyeloid Differentiation Factor 88Tlr2 protein, mouseToll-Like Receptor 2innate immunitymacrophagesignal transductionSNPToll-like receptor (TLR)

Identifiers

PMID28442574
PMCPMC5481573
OpenAlexW2607981715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.