Evidence map›Paper›PMID 28442547›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Biosynthesis of proresolving lipid mediators by vascular cells and tissues.

Anuran Chatterjee, Sevan Komshian, Brian E Sansbury, Bian Wu, Giorgio Mottola, Mian Chen, Matthew Spite, Michael S Conte

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
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  9. Article
  10. Roles of Resolvins in Chronic Inflammatory Response.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Expression and function of resolvin RvD1European journal of oral sciences · 2022
    Article
  13. Review
  14. Molecular Pharmacology of Inflammation Resolution in Atherosclerosis.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Proresolving receptor tames inflammation in atherosclerosis.The Journal of clinical investigation · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Anuran ChatterjeeCardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
Sevan KomshianSchool of Medicine, Boston University, Boston, Massachusetts, USA.
Brian E SansburyCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Bian WuCardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
Giorgio MottolaCardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
Mian ChenCardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
Matthew SpiteCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Michael S ConteCardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA; michael.conte2@ucsf.edu.
Cardiovascular Institute Hospital · JPBrigham and Women's Hospital · USUniversity of California, San Francisco · USBoston University · US

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PETASIS, NICOS A · 2011 to 2020
$14.8M
Role of Inflammation-Resolving Lipid Mediators In Ischemic RevascularizationR01HL106173 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SPITE, MATTHEW R · 2011 to 2023
$5.7M
Specialized lipid mediators and mechanisms of resolution in vascular injuryR01HL119508 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONTE, MICHAEL S · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL106173NHLBI NIH HHS R01 HL119508NIGMS NIH HHS P01 GM095467
6 · The paper itself

Abstract

Recent evidence suggests that specialized proresolving lipid mediators (SPMs) generated from docosahexaenoic acid (DHA) can modulate the vascular injury response. However, cellular sources for these autacoids within the vessel wall remain unclear. Here, we investigated whether isolated vascular cells and tissues can produce SPMs and assessed expression and subcellular localization of the key SPM biosynthetic enzyme 5-lipoxygenase (LOX) in vascular cells. Intact human arteries incubated with DHA

Indexed as

AntibodiesArachidonate 5-LipoxygenaseCells, CulturedCytokinesDocosahexaenoic AcidsEndothelial CellsGene Expression RegulationHumansInflammationLeukocytesLipid MetabolismMolecular StructureMyocytes, Smooth MuscleProtein TransportReceptors, Formyl PeptideReceptors, G-Protein-CoupledALOX5 protein, humanAntibodiesArachidonate 5-LipoxygenaseCytokinesDocosahexaenoic AcidsFPR2 protein, humanGPR32 protein, humanReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, Lipoxinresolvin D1omega-3 fatty acidsresolution of inflammationresolvins

Identifiers

PMID28442547
PMCPMC6207217
OpenAlexW2608740477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.