ArticleThe Journal of endocrinology2017
Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice.
Article in The Journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Terazosin, a repurposed GPR119 agonist, ameliorates mitophagy and β-cell function in NAFPD by inhibiting MST1-Foxo3a signalling pathway.Cell proliferation · 2025Article
- Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review.World journal of gastroenterology · 2025Review
- Pathophysiological Mechanisms and Clinical Associations of Non-Alcoholic Fatty Pancreas Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Fatty Pancreas: Linking Pancreas Pathophysiology to Nonalcoholic Fatty Liver Disease.Journal of clinical and translational hepatology · 2022Review
- STK25 inhibits PKA signaling by phosphorylating PRKAR1A.Cell reports · 2022Article
- Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective.Communications biology · 2022Article
- Nonalcoholic Fatty Pancreas Disease: Role in Metabolic Syndrome, "Prediabetes," Diabetes and Atherosclerosis.Digestive diseases and sciences · 2022Review
- Nonalcoholic fatty pancreas disease: An emerging clinical challenge.World journal of clinical cases · 2021Review
- Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.JCI insight · 2020Article
- Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.Cellular and molecular gastroenterology and hepatology · 2019Article
- Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans.Cancer science · 2018Review
- STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer.Journal of experimental & clinical cancer research : CR · 2018Article
- Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.Hepatology communications · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterising the molecular networks that negatively regulate pancreatic β-cell function is essential for understanding the underlying pathogenesis and developing new treatment strategies for type 2 diabetes. We recently identified serine/threonine protein kinase 25 (STK25) as a critical regulator of ectopic fat storage, meta-inflammation, and fibrosis in liver and skeletal muscle. Here, we assessed the role of STK25 in control of progression of non-alcoholic fatty pancreas disease in the context of chronic exposure to dietary lipids in mice. We found that overexpression of STK25 in high-fat-fed transgenic mice aggravated diet-induced lipid storage in the pancreas compared with that of wild-type controls, which was accompanied by exacerbated pancreatic inflammatory cell infiltration, stellate cell activation, fibrosis and apoptosis. Pancreas of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.