ArticleAmerican journal of physiology. Endocrinology and metabolism2017
Low-dose leptin infusion in the fourth ventricle of rats enhances the response to third-ventricle leptin injection.
Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Secretion Patterns of Leptin: A Key Component in the Regulation of Energy Homeostasis and Its Therapeutic Applications.Biomolecules · 2026Review
- Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats.American journal of physiology. Endocrinology and metabolism · 2025Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats.Neuropharmacology · 2021Article
- Consuming sucrose solution promotes leptin resistance and site specifically modifies hypothalamic leptin signaling in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity.American journal of physiology. Endocrinology and metabolism · 2020Article
- Leptin receptor-expressing neurons in ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions.American journal of physiology. Endocrinology and metabolism · 2019Article
- Low-dose infusions of leptin into the nucleus of the solitary tract increase sensitivity to third ventricle leptin.American journal of physiology. Endocrinology and metabolism · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
We previously reported that low-dose leptin infusions into the third or fourth ventricle that do not affect energy balance when given independently cause rapid weight loss when given simultaneously. Therefore, we tested whether hindbrain leptin enhances the response to forebrain leptin or whether forebrain leptin enhances the response to hindbrain leptin. Rats received fourth-ventricle infusions of saline or 0.01, 0.1, 0.3, or 0.6 μg leptin/day for 13 days. On
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.