ArticleAnaerobe2017
Distinct roles for dietary lipids and Porphyromonas gingivalis infection on atherosclerosis progression and the gut microbiota.
Article in Anaerobe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Gut microbiota and derived metabolites mediate obstructive sleep apnea induced atherosclerosis.Gut microbes · 2025Article
- The Systemic Link Between Oral Health and Cardiovascular Disease: Contemporary Evidence, Mechanisms, and Risk Factor Implications.Diseases (Basel, Switzerland) · 2025Review
- The Oral-Gut-Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke.CNS neuroscience & therapeutics · 2024Review
- Periodontal bacteria influence systemic diseases through the gut microbiota.Frontiers in cellular and infection microbiology · 2024Review
- The interaction between oral microbiota and gut microbiota in atherosclerosis.Frontiers in cardiovascular medicine · 2024Review
- Oral-gut axis as a novel biological mechanism linking periodontal disease and systemic diseases: A review.The Japanese dental science review · 2023Review
- The interplay between oral microbiota, gut microbiota and systematic diseases.Journal of oral microbiology · 2023Review
- Epigenetics and Gut Microbiota Crosstalk: A potential Factor in Pathogenesis of Cardiovascular Disorders.Bioengineering (Basel, Switzerland) · 2022Review
- Polyphenols-Gut-Heart: An Impactful Relationship to Improve Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Periodontitis and Other Risk Factors Related to Myocardial Infarction and Its Follow-Up.Journal of clinical medicine · 2022Article
- Chronic apical periodontitis exacerbates atherosclerosis in apolipoprotein E-deficient mice and leads to changes in the diversity of gut microbiota.International endodontic journal · 2022Article
- Inflammatory response of gut, spleen, and liver in mice induced by orally administeredJournal of oral microbiology · 2022Article
- The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium.Bioengineering (Basel, Switzerland) · 2021Review
- Can manipulation of gut microbiota really be transformed into an intervention strategy for cardiovascular disease management?Folia microbiologica · 2021Review
- Diet-Induced Non-alcoholic Fatty Liver Disease and Associated Gut Dysbiosis Are Exacerbated by Oral Infection.Frontiers in oral health · 2021Article
- Anti-atherosclerotic vaccination againstPeerJ · 2021Article
- Multifaceted Impacts of Periodontal Pathogens in Disorders of the Intestinal Barrier.Frontiers in immunology · 2021Review
- Oral microbiota and oral cancer: Review.Oncology reviews · 2020Article
- The Role of Microbiologic Agents in the Progression of the Atherosclerosis: a Comprehensive Review.Journal of the Saudi Heart Association · 2020Review
- Alzheimer's Disease-Like Pathology Triggered byFrontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mounting evidence in humans supports an etiological role for the microbiota in inflammatory atherosclerosis. Atherosclerosis is a progressive disease characterized by accumulation of inflammatory cells and lipids in vascular tissue. While retention of lipoprotein into the sub-endothelial vascular layer is believed to be the initiating stimulus leading to the development of atherosclerosis, activation of multiple pathways related to vascular inflammation and endothelial dysfunction sustain the process by stimulating recruitment of leukocytes and immune cells into the sub-endothelial layer. The Gram-negative oral pathogen Porphyromonas gingivalis has been associated with the development and acceleration of atherosclerosis in humans and these observations have been validated in animal models. It has been proposed that common mechanisms of immune signaling link stimulation by lipids and pathogens to vascular inflammation. Despite the common outcome of P. gingivalis and lipid feeding on atherosclerosis progression, we established that these pro-atherogenic stimuli induced distinct gene signatures in the ApoE
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.