Evidence map›Paper›PMID 28442257›Full record

ArticleClinical biochemistry2017

Cocaine use is associated with a higher prevalence of elevated ST2 concentrations.

Xander M R van Wijk, Eric Vittinghoff, Alan H B Wu, Kara L Lynch, Elise D Riley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Impact of multiple substance use on circulating ST2, a biomarker of adverse cardiac remodelling, in women.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xander M R van WijkDepartment of Laboratory Medicine, Zuckerberg San Francisco General, University of California, San Francisco, CA, USA. Electronic address: Xander.VanWijk@ucsf.edu.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Alan H B WuDepartment of Laboratory Medicine, Zuckerberg San Francisco General, University of California, San Francisco, CA, USA.
Kara L LynchDepartment of Laboratory Medicine, Zuckerberg San Francisco General, University of California, San Francisco, CA, USA.
Elise D RileyDivision of HIV, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USSan Francisco General Hospital · US

Funding

Impact of Cocaine and Polydrug Use on Cranial Small Vessel DiseaseR01DA037012 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RILEY, ELISE D. · 2014 to 2018
$4.1M
Mentoring patient-oriented research on the health consequences of polydrug useK24DA039780 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RILEY, ELISE D. · 2015 to 2025
$1.9M
NIDA NIH HHS K24 DA039780NIDA NIH HHS R01 DA037012
6 · The paper itself

Abstract

backgroundCocaine is a well-known risk factor for acute cardiac events, but the effects in users outside of acute events are less clear. We investigated a possible association between cocaine use and the concentration of a novel biomarker for cardiac stress and heart failure, ST2.

methodsA case-control study was conducted to compare ST2 concentrations by the presence of cocaine in patients presenting for care, but not cardiac care, at an urban safety net hospital.

resultsIn samples taken from 100 cocaine-positive and 100 cocaine-negative patients, the presence of cocaine was associated with ST2 concentrations>35ng/mL. Serum concentrations of benzoylecgonine, a major cocaine metabolite, were significantly correlated with ST2 concentrations.

conclusionsCocaine use is associated with subclinical cardiac stress and damage outside of acute cardiac events. This information could add to better stratification of cocaine users with elevated ST2 concentrations who may be at higher risk for developing heart failure and other cardiac complications.

Indexed as

Asymptomatic DiseasesAdultBiomarkersBiotransformationCase-Control StudiesCocaineCocaine-Related DisordersFemaleHeart DiseasesHospitals, GeneralHumansIllicit DrugsInterleukin-1 Receptor-Like 1 ProteinMaleMiddle AgedRetrospective StudiesbenzoylecgonineBiomarkersCocaineIL1RL1 protein, humanIllicit DrugsInterleukin-1 Receptor-Like 1 ProteinBenzoylecgonineCardiac stressCocaineDrugs of abuseST2

Identifiers

PMID28442257
PMCPMC5638657
OpenAlexW2606776271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.