ArticleDevelopmental cognitive neuroscience2018
Functional hyperconnectivity vanishes in children with developmental dyscalculia after numerical intervention.
Article in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Mathematics Skills in Epilepsy: A Systematic Review and Meta-Analysis.Neuropsychology review · 2024Pooled it
- Examination of common and unique brain regions for atypical reading and math: a meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Pooled it
- Distinct neural representational changes following cross-format number tutoring in children with mathematical difficulties.NPJ science of learning · 2025Article
- Altered Effective Connectivity of the Numerical Brain in Children With Developmental Dyscalculia.Journal of neuroscience research · 2025Article
- Functional connectivity and GABAergic signaling modulate the enhancement effect of neurostimulation on mathematical learning.PLoS biology · 2025Article
- The effect of a 2-month abacus training on students with developmental dyscalculia.Cognitive processing · 2025Article
- Short-term number sense training recapitulates long-term neurodevelopmental changes from childhood to adolescence.Developmental science · 2024Article
- Are numerical abilities determined at early age? A brain morphology study in children and adolescents with and without developmental dyscalculia.Developmental cognitive neuroscience · 2024Article
- From brain to education through machine learning: Predicting literacy and numeracy skills from neuroimaging data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Activation and functional connectivity of cerebellum during reading and during arithmetic in children with combined reading and math disabilities.Frontiers in neuroscience · 2024Article
- The two-network framework of number processing: a step towards a better understanding of the neural origins of developmental dyscalculia.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The brain lateralization and development of math functions: progress since Sperry, 1974.Frontiers in human neuroscience · 2023Review
- Training causes activation increase in temporo-parietal and parietal regions in children with mathematical disabilities.Brain structure & function · 2022Article
- The selective contributions of right cerebellar lobules to reading.Brain structure & function · 2022Article
- Increased structural covariance in brain regions for number processing and memory in children with developmental dyscalculia.Journal of neuroscience research · 2022Article
- Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.PLoS biology · 2021Article
- Developmental brain dynamics of numerical and arithmetic abilities.NPJ science of learning · 2021Review
- Emerging neurodevelopmental perspectives on mathematical learning.Developmental review : DR · 2021Article
- Thalamus is a common locus of reading, arithmetic, and IQ: Analysis of local intrinsic functional properties.Brain and language · 2020Article
- Persistent Effects of Musical Training on Mathematical Skills of Children With Developmental Dyscalculia.Frontiers in psychology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental dyscalculia (DD) is a developmental learning disability associated with deficits in processing numerical and mathematical information. Although behavioural training can reduce these deficits, it is unclear which neuronal resources show a functional reorganization due to training. We examined typically developing (TD) children (N=16, mean age: 9.5 years) and age-, gender-, and handedness-matched children with DD (N=15, mean age: 9.5 years) during the performance of a numerical order task with fMRI and functional connectivity before and after 5-weeks of number line training. Using the intraparietal sulcus (IPS) as seed region, DD showed hyperconnectivity in parietal, frontal, visual, and temporal regions before the training controlling for age and IQ. Hyperconnectivity disappeared after training, whereas math abilities improved. Multivariate classification analysis of task-related fMRI data corroborated the connectivity results as the same group of TD could be discriminated from DD before but not after number line training (86.4 vs. 38.9%, respectively). Our results indicate that abnormally high functional connectivity in DD can be normalized on the neuronal level by intensive number line training. As functional connectivity in DD was indistinguishable to TD's connectivity after training, we conclude that training lead to a re-organization of inter-regional task engagement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.