ArticleCardiovascular diabetology2017
Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008-2011).
Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 56 citations in OpenAlex.
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- Low leg fat mass is associated with low insulin sensitivity, inflammatory markers, and β-cell dysfunction in non-obese Japanese people.Scientific reports · 2025Article
- The relationship between MAFLD and CVD in a health check-up Chinese population: a prospective cohort study.Therapeutic advances in chronic disease · 2025Article
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- Adipose tissue insulin resistance index was inversely associated with gluteofemoral fat and skeletal muscle mass in Japanese women.Scientific reports · 2024Article
- Correlation between serum trimethylamine-N-oxide and body fat distribution in middle-aged and older adults: a prospective cohort study.Nutrition journal · 2024Article
- Associations of adipose insulin resistance index with leg (gluteofemoral) fat (inverse) and serum alanine aminotransferase (positive) in young Japanese women.Metabolism open · 2024Article
- Cardiometabolic traits mediating the effect of education on the risk of DKD and CKD: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- The L-shaped association of mid-upper arm circumference with all-cause and cause-specific mortality in US adults: a population-based prospective cohort study.BMC public health · 2023Article
- Long-term cardiovascular outcomes differ across metabolic dysfunction-associated fatty liver disease subtypes among middle-aged population.Hepatology international · 2022Article
- Prevalence and predictors of metabolically healthy obesity in severely obese Asian children.Pediatric research · 2022Article
- How Unawareness of Weight Excess Can Increase Cardiovascular Risk?Journal of clinical medicine · 2022Article
- Human Milk Macronutrients and Bioactive Molecules and Development of Regional Fat Depots in Western Australian Infants during the First 12 Months of Lactation.Life (Basel, Switzerland) · 2022Article
- Cardiovascular Risk Is Elevated in Lean Subjects with Nonalcoholic Fatty Liver Disease.Gut and liver · 2022Article
- Leg and arm adiposity is inversely associated with diastolic hypertension in young and middle-aged United States adults.Clinical hypertension · 2022Article
- The impact of body composition and fat distribution on blood pressure in young and middle-aged adults.Frontiers in nutrition · 2022Article
- Risk factors for hypertension and diabetes comorbidity in a Korean population: A cross-sectional study.PloS one · 2022Article
- Body composition of the upper limb associated with hypertension, hypercholesterolemia, and diabetes.Frontiers in endocrinology · 2022Article
- Synergistic associations of visual and self-reported hearing acuity with low handgrip strength in older adults: a population-based cross-sectional study.BMC geriatrics · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough central fat is a well-known risk factor for cardiovascular disease (CVD) and cardiometabolic disorders, the effect of other regional fats or muscle distribution on CVD risk has not been fully investigated.
methodsThis was a cross-sectional study using nationally representative samples of 15,686 subjects from the 2008-2011 Korea National Health and Nutrition Examination Survey. Individual CVD risk was evaluated in adults aged ≥20 without prior CVD, using atherosclerotic cardiovascular disease (ASCVD) risk equations according to the 2013 ACC/AHA guidelines. Body composition was assessed by dual X-ray absorptiometry.
resultsRatio of leg fat to total fat (LF/TF ratio) was the most predictive for CVD among body fat or muscle distribution parameters (AUC = 0.748, 95% CI 0.741-0.755). ASCVD risk score was gradually increased with decreased LF/TF ratio (P < 0.001), and individuals whose LF/TF ratio in lowest tertile tended to belong to the high-risk (10-year risk >10%) group compared to those in the highest tertile (OR = 6.25, 95% CI 5.60-6.98). Subjects in the lowest tertile showed increased risk of cardiometabolic risk factor components including obesity, hypertension, diabetes, dyslipidemia, chronic kidney disease, and albuminuria (OR range 2.57-11.24, all P < 0.001). In addition, a higher LF/TF ratio was associated with decreased ASCVD risk, even in subjects with multiple CVD risk factors. Multiple logistic regression analyses also demonstrated this association (OR = 1.85, 95% CI 1.36-2.52).
conclusionsAmong various body composition parameters, LF/TF ratio was superior in predicting higher CVD risk and a higher LF/TF ratio was independently associated with decreased risk of CVD and each cardiometabolic risk factor.
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