ReviewChemical reviews2017
Natural [4 + 2]-Cyclases.
Review in Chemical reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 150 citations in OpenAlex.
- Manganese-CatalyzedACS omega · 2026Article
- One-Step Rh-Catalyzed Atom-Economical Cyclization of Acetophenones and Methyl Propiolate Affording Isoquinoline Derivatives.ACS omega · 2026Article
- Electric fields enhance Diels-Alderase catalysis in abyssomicin C biosynthesis.Chemical communications (Cambridge, England) · 2026Article
- Activatable self-reporting cyclization reaction for in-cell synthesis of cyclocyanines.Chemical science · 2026Article
- The Diels-Alder Reaction as a Key Step in Natural Product Synthesis.Progress in the chemistry of organic natural products · 2026Review
- Biocatalyzed and Photochemical Formal [2+2] Cycloaddition of Euphoboetirane A: A Route to a Fused Pentacyclic Diterpene Skeleton.Organic letters · 2025Article
- A New Insight into the Molecular Mechanism of the Reaction between 2-Methoxyfuran and Ethyl (Molecules (Basel, Switzerland) · 2024Article
- Delineation of the complete reaction cycle of a natural Diels-Alderase.Chemical science · 2024Article
- Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis.Nature communications · 2024Article
- Review
- Visible-light-enabled stereoselective synthesis of functionalized cyclohexylamine derivativesChemical science · 2024Article
- Review
- Elucidation of the stereocontrol mechanisms of the chemical and biosynthetic intramolecular Diels-Alder cycloaddition for the formation of bioactive decalins.RSC advances · 2023Article
- Tandem intermolecular [4 + 2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis.Nature chemistry · 2023Article
- Back-to-back cycloadditions in nature.Nature chemistry · 2023Article
- Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.Chembiochem : a European journal of chemical biology · 2023Article
- Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure-activity relationship, and biosynthesis.Archives of pharmacal research · 2023Review
- Advances on the biosynthesis of pyridine rings.Engineering microbiology · 2023Review
- Pericyclases for cycloaddition.National science review · 2022Article
- Combining iminium and supramolecular catalysis for the [4 + 2] cycloaddition ofOrganic & biomolecular chemistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
[4 + 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of many structurally complex natural products. A relatively small collection of enzymes from these pathways have been demonstrated to increase rates of cyclization and impose stereochemical constraints on the reactions. While mechanistic investigation of these enzymes is just beginning, recent studies have provided new insights with implications for understanding their biosynthetic roles, mechanisms of catalysis, and evolutionary origin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.