Evidence map›Paper›PMID 28441734›Full record

ReviewViruses2017

Chloroviruses Have a Sweet Tooth.

James L Van Etten, Irina Agarkova, David D Dunigan, Michela Tonetti, Christina De Castro, Garry A Duncan

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 186 citations in OpenAlex.

  1. Article
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  6. Insights into substrate binding and utilization by hyaluronan synthase.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
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  10. Article
  11. Article
  12. Article
  13. Frontiers in microbiology · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James L Van EttenDepartment of Plant Pathology and Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900, USA. jvanetten1@unl.edu.
Irina AgarkovaDepartment of Plant Pathology and Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900, USA. irina@unl.edu.
David D DuniganDepartment of Plant Pathology and Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900, USA. ddunigan2@unl.edu.
Michela TonettiDepartment of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova Viale Benedetto XV/1, 16132 Genova, Italy. tonetti@unige.it.
Christina De CastroDepartment of Agricultural Sciences, University of Napoli, Via Università 100, 80055 Portici, NA, Italy. decastro@unina.it.
Garry A DuncanDepartment of Biology, Nebraska Wesleyan University, Lincoln, NE 68504-2796, USA. gduncan@nebrwesleyan.edu.
University of Nebraska–Lincoln · USNebraska Wesleyan University · US

Funding

Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
NIGMS NIH HHS P30 GM103509
6 · The paper itself

Abstract

Chloroviruses are large double-stranded DNA (dsDNA) viruses that infect certain isolates of chlorella-like green algae. They contain up to approximately 400 protein-encoding genes and 16 transfer RNA (tRNA) genes. This review summarizes the unexpected finding that many of the chlorovirus genes encode proteins involved in manipulating carbohydrates. These include enzymes involved in making extracellular polysaccharides, such as hyaluronan and chitin, enzymes that make nucleotide sugars, such as GDP-L-fucose and GDP-D-rhamnose and enzymes involved in the synthesis of glycans attached to the virus major capsid proteins. This latter process differs from that of all other glycoprotein containing viruses that traditionally use the host endoplasmic reticulum and Golgi machinery to synthesize and transfer the glycans.

Indexed as

Genes, ViralMetabolic Networks and PathwaysCarbohydrate MetabolismChlorellaPhycodnaviridaechitin synthesischlorovirusesgiant virusesglycan structuresglycan synthesisglycoproteinshyaluronan synthesisnucleotide sugar synthesis

Identifiers

PMID28441734
PMCPMC5408694
OpenAlexW2608389566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.