Evidence map›Paper›PMID 28441719›Full record

ArticleNutrients2017

Suppression of Oxidative Stress and NFκB/MAPK Signaling by Lyophilized Black Raspberries for Esophageal Cancer Prevention in Rats.

Ni Shi, Fang Chen, Xiaoli Zhang, Steven K Clinton, Xiaofei Tang, Zheng Sun, Tong Chen

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Chemopreventive Potential of Artemisinin andInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Berries vs. Disease: Revenge of the Phytochemicals.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  8. Nuclear factor kappa B expression in non-small cell lung cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Anthocyanins in Colorectal Cancer Prevention Review.Antioxidants (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Review
  19. Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword.Frontiers in bioengineering and biotechnology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ni ShiDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA. ni.shi@osumc.edu.
Fang ChenCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. chenfangch@sina.com.
Xiaoli ZhangDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA. xiaoli.zhang@osumc.edu.
Steven K ClintonDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA. steven.clinton@osumc.edu.
Xiaofei TangDivision of Oral Pathology, Beijing Institute of Dental Research, Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing 100050, China. xftang10@ccmu.edu.cn.
Zheng SunDivision of Oral Pathology, Beijing Institute of Dental Research, Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing 100050, China. sunzheng12@vip.sohu.com.
Tong ChenDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA. tong.chen@osumc.edu.
Capital Medical University · CNThe Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USChina Agricultural University · CN

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Validation studies for interactive omics: Black raspberry metabolites and the oral microbiome in smokersU01CA188250 · NCI · OHIO STATE UNIVERSITY · PI CLINTON, STEVEN K, KUMAR, PURNIMA · 2014 to 2019
$3.6M
Oncogenic Function of Ca2+ Channel Orai1 in Esophageal CarcinogenesisR01CA185055 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG, PAN, ZUI · 2015 to 2019
$1.6M
Combinational Approaches to the Chemoprevention of Esophageal CancerR01CA131073 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG · 2008 to 2012
$1.6M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA131073NCI NIH HHS R01 CA185055NCI NIH HHS U01 CA188250
6 · The paper itself

Abstract

Research in the laboratory has shown that lyophilized black raspberries (BRB) significantly inhibit

Indexed as

AnimalsAntineoplastic Agents, PhytogenicAntioxidantsDimethylnitrosamineEsophageal NeoplasmsGene Expression Regulation, EnzymologicGlutathione PeroxidaseHydrogen PeroxideLipid PeroxidesMitogen-Activated Protein Kinase KinasesNF-kappa BOxidative StressRatsRubusSuperoxide DismutaseSuperoxide Dismutase 2Antineoplastic Agents, PhytogenicAntioxidantsDimethylnitrosamineGlutathione PeroxidaseHydrogen PeroxideLipid PeroxidesMitogen-Activated Protein Kinase KinasesNF-kappa BnitrosobenzylmethylamineSuperoxide DismutaseSuperoxide Dismutase 2black raspberriesesophageal cancerMAPKNFκBoxidative stress

Identifiers

PMID28441719
PMCPMC5409752
OpenAlexW2608348693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.