ArticlePloS one2017
Hemodynamics and gas exchange during chest compressions in neonatal resuscitation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Neonatal resuscitation for bradycardia (HR < 60 bpm)-an alternate approach using an ovine model.Pediatric research · 2026Article
- Direct Umbilical Vein Injection of Epinephrine with Cut-Cord Milking in an Ovine Model of Neonatal Resuscitation.Children (Basel, Switzerland) · 2024Article
- Neonatal resuscitation with continuous chest compressions and high frequency percussive ventilation in preterm lambs.Pediatric research · 2024Article
- Femoral Occlusion during Neonatal Cardiopulmonary Resuscitation Improves Outcomes in an Ovine Model of Perinatal Cardiac Arrest.Children (Basel, Switzerland) · 2023Article
- Optimal oxygen use in neonatal advanced cardiopulmonary resuscitation-a literature review.Pediatric medicine (Hong Kong, China) · 2023Article
- Masked Randomized Trial of Epinephrine versus Vasopressin in an Ovine Model of Perinatal Cardiac Arrest.Children (Basel, Switzerland) · 2023Article
- Technical feasibility of multimodal imaging in neonatal hypoxic-ischemic encephalopathy from an ovine model to a human case series.Frontiers in pediatrics · 2023Article
- Inadequate Bioavailability of Intramuscular Epinephrine in a Neonatal Asphyxia Model.Frontiers in pediatrics · 2022Article
- Return of Spontaneous Circulation Depends on Cardiac Rhythm During Neonatal Cardiac Arrest in Asphyxiated Newborn Animals.Frontiers in pediatrics · 2021Article
- Protection from systemic pyruvate at resuscitation in newborn lambs with asphyxial cardiac arrest.Physiological reports · 2020Article
- Cardiopulmonary Resuscitation of Asystolic Newborn Lambs Prior to Umbilical Cord Clamping; the Timing of Cord Clamping Matters!Frontiers in physiology · 2020Article
- Chest Compressions for Bradycardia during Neonatal Resuscitation-Do We Have Evidence?Children (Basel, Switzerland) · 2019Review
- Epinephrine in Neonatal Resuscitation.Children (Basel, Switzerland) · 2019Review
- Chest Compressions in the Delivery Room.Children (Basel, Switzerland) · 2019Review
- Effect of various inspired oxygen concentrations on pulmonary and systemic hemodynamics and oxygenation during resuscitation in a transitioning preterm model.Pediatric research · 2018Article
- A family of NICU graduates!Pediatric research · 2018Article
- The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
purposeCurrent knowledge about pulmonary/systemic hemodynamics and gas exchange during neonatal resuscitation in a model of transitioning fetal circulation with fetal shunts and fluid-filled alveoli is limited. Using a fetal lamb asphyxia model, we sought to determine whether hemodynamic or gas-exchange parameters predicted successful return of spontaneous circulation (ROSC).
methodsThe umbilical cord was occluded in 22 lambs to induce asphyxial cardiac arrest. Following five minutes of asystole, resuscitation as per AHA-Neonatal Resuscitation Program guidelines was initiated. Hemodynamic parameters and serial arterial blood gases were assessed during resuscitation.
resultsROSC occurred in 18 lambs (82%) at a median (IQR) time of 120 (105-180) seconds. There were no differences in hemodynamic parameters at baseline and at any given time point during resuscitation between the lambs that achieved ROSC and those that did not. Blood gases at arrest prior to resuscitation were comparable between groups. However, lambs that achieved ROSC had lower PaO2, higher PaCO2, and lower lactate during resuscitation. Increase in diastolic blood pressures induced by epinephrine in lambs that achieved ROSC (11 ±4 mmHg) did not differ from those that were not resuscitated (10 ±6 mmHg). Low diastolic blood pressures were adequate to achieve ROSC.
conclusionsHemodynamic parameters in a neonatal lamb asphyxia model with transitioning circulation did not predict success of ROSC. Lactic acidosis, higher PaO2 and lower PaCO2 observed in the lambs that did not achieve ROSC may represent a state of inadequate tissue perfusion and/or mitochondrial dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.