ArticlePloS one2017
Sex discordance in asthma and wheeze prevalence in two longitudinal cohorts.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Models for estimating and projecting global, regional and national prevalence and disease burden of asthma: a systematic review.Journal of global health · 2020Pooled it
- Genetic and observational evidence supports a causal role of sex hormones on the development of asthma.Thorax · 2019Pooled it
- Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.Mutation research. Reviews in mutation researchPooled it
- Sex and Pubertal Status in Relation to Wheezing, Asthma, and Lung Function Development in a Multi-Ethnic Population-Based Prospective Cohort.Pediatric pulmonology · 2025Article
- Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age.Genome medicine · 2025Article
- Influence of Biological Sex and Congenital Iron Deficiency on Neonatal Cytokine Responses.Nutrients · 2024Article
- Socioeconomic position, bronchiolitis and asthma in children: counterfactual disparity measures from a national birth cohort study.International journal of epidemiology · 2023Article
- Sex-specific associations of asthma acquisition with changes in DNA methylation during adolescence.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice.Journal of neuroimmunology · 2021Article
- Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study.BMC pulmonary medicine · 2019Article
- Genome-wide analysis revealed sex-specific gene expression in asthmatics.Human molecular genetics · 2019Article
- Prevalence of asthma and other allergic conditions in adults in Khuzestan, southwest Iran, 2018.BMC public health · 2019Article
- Comparison of the Associations of Early-Life Factors on Wheezing Phenotypes in Preterm-Born Children and Term-Born Children.American journal of epidemiology · 2019Article
- Epidemiology of asthma and associated factors in an urban Pakistani population: adult asthma study-Karachi.BMC pulmonary medicine · 2018Article
- Childhood asthma prevalence: cross-sectional record linkage study comparing parent-reported wheeze with general practitioner-recorded asthma diagnoses from primary care electronic health records in Wales.BMJ open respiratory research · 2018Article
- Association between Traffic Related Air Pollution and the Development of Asthma Phenotypes in Children: A Systematic Review.International journal of chronic diseases · 2018Review
- Allergy-related disorders (ARDs) among Ethiopian primary school-aged children: Prevalence and associated risk factors.PloS one · 2018Article
- Epigenome-wide association study of asthma and wheeze in childhood and adolescence.Clinical epigenetics · 2017Article
- Prevalence and Risk Factors of Asthma, Rhinitis, and Eczema and Their Multimorbidity among Young Adults in Kuwait: A Cross-Sectional Study.BioMed research international · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sex discordance in asthma prevalence has been previously reported, with higher prevalence in males before puberty, and in females after puberty; the adolescent "switch". However, cross-sectional studies have suggested a narrowing of this discordance in recent decades. We used a combination of cross-sectional and longitudinal modelling to examine sex differences in asthma, wheeze and longitudinal wheezing phenotypes in two UK birth cohorts, the Avon Longitudinal Study of Parents and Children (ALSPAC; born 1991-92 with data from age 0-18 years) and the Millennium Cohort Study (MCS; born 2000-02 with data from age 3-10 years). We derived measures of asthma and wheeze from questionnaires completed by mothers and cohort children. Previously-derived ALSPAC wheezing phenotype models were applied to MCS. Males had a higher prevalence of asthma at 10.7 years in ALSPAC (OR 1.45 95%CI: 1.26, 1.66 n = 7778 for current asthma) and MCS (OR 1.42 95%CI: 1.29, 1.56 n = 6726 for asthma ever) compared to females, decreasing in ALSPAC after puberty (OR 0.94 95%CI: 0.79, 1.11 n = 5023 for current asthma at 16.5 years). In longitudinal models using restricted cubic splines, males had a clear excess for asthma in the last 12 months and wheeze in the last 12 months up until 16.5 years of age in ALSPAC. Males had an increased risk of all derived longitudinal wheezing phenotypes in MCS when compared to never wheeze and no evidence of being at lower risk of late wheeze when compared to early wheeze. By comparing data in two large, contemporary cohorts we have shown the persistence of sex discordance in childhood asthma, with no evidence that the sex discordance is narrowing in recent cohorts.
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Registered trials
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