ReviewAnnual review of neuroscience2017
Neural Circuitry of Reward Prediction Error.
Review in Annual review of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
192 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis of human prediction error for incentives, perception, cognition, and action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders.The American journal of psychiatry · 2021Pooled it
- The Signaling and Pharmacology of the Dopamine D1 Receptor.Frontiers in cellular neuroscience · 2021Pooled it
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.Communications biology · 2026Article
- Cerebellar neural populations orchestrate dopamine reward signaling with single-trial precision.Nature communications · 2026Article
- Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability.Translational psychiatry · 2026Review
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- Article
- Dopamine Response to Unexpected Aversive Outcomes Drives the Return of Extinguished Fear.Brain sciences · 2026Article
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- A shared predictive architecture in the sensory cortex for statistical and reward-based learning.Current opinion in neurobiology · 2026Review
- Dopamine in the ventral and tail of striatum supports global and local evaluation in reward-threat conflict.bioRxiv : the preprint server for biology · 2026Article
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- Distinct roles of cortical layer 5 subtypes in associative learning.Nature communications · 2026Article
- Predictive coding of reward in the hippocampus.Nature · 2026Article
- Encoding of odor information and reward anticipation in anterior cortical amygdaloid nucleus.iScience · 2026Article
- A ventral tegmental area GABAergic projection to the ventral pallidum regulates value-based decision making in mice.bioRxiv : the preprint server for biology · 2026Article
- Dopamine signatures of excessive and compulsive cocaine and fentanyl use.bioRxiv : the preprint server for biology · 2026Article
- The Temporal Scaffolding of Sensory Organization.Annual review of psychology · 2026Review
132 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dopamine neurons facilitate learning by calculating reward prediction error, or the difference between expected and actual reward. Despite two decades of research, it remains unclear how dopamine neurons make this calculation. Here we review studies that tackle this problem from a diverse set of approaches, from anatomy to electrophysiology to computational modeling and behavior. Several patterns emerge from this synthesis: that dopamine neurons themselves calculate reward prediction error, rather than inherit it passively from upstream regions; that they combine multiple separate and redundant inputs, which are themselves interconnected in a dense recurrent network; and that despite the complexity of inputs, the output from dopamine neurons is remarkably homogeneous and robust. The more we study this simple arithmetic computation, the knottier it appears to be, suggesting a daunting (but stimulating) path ahead for neuroscience more generally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.