Evidence map›Paper›PMID 28441069›Full record

ArticleHuman vaccines & immunotherapeutics2017

Low doses of IgG from atopic individuals can modulate in vitro IFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach.

Fábio da Ressureição Sgnotto, Marília Garcia de Oliveira, Aline Aparecida de Lima Lira, Luciana Bento-de-Souza, Alberto José da Silva Duarte, Jefferson Russo Victor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fábio da Ressureição Sgnottoa Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology , Medical School, University of São Paulo , São Paulo , Brazil.
Marília Garcia de Oliveiraa Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology , Medical School, University of São Paulo , São Paulo , Brazil.
Aline Aparecida de Lima Liraa Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology , Medical School, University of São Paulo , São Paulo , Brazil.
Luciana Bento-de-Souzaa Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology , Medical School, University of São Paulo , São Paulo , Brazil.
Alberto José da Silva Duartea Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology , Medical School, University of São Paulo , São Paulo , Brazil.
Jefferson Russo Victora Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology , Medical School, University of São Paulo , São Paulo , Brazil.ORCID 0000-0001-6092-8394
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulatory effect of allergic responses induced by IgG antibodies on human intra-thymic cells has not been reported in the literature. The aim of this study was to evaluate the possible differential effect of purified IgG from atopic and non-atopic individuals on human intra-thymic αβT cell cytokine production. Thymic tissues were obtained from 14 patients who were less than 7 d old. Additionally, blood samples were collected from atopic and non-atopic volunteers. Thymocytes and peripheral blood mononuclear cells were cultured with purified atopic or non-atopic IgG, and intracellular cytokine production was assessed. Purified IgG did not influence the frequency or viability of human intra-thymic αβT cells. Purified non-atopic IgG induced greater IFN-γ production by intra-thymic CD4+CD8+ T cells than did the mock treatment and atopic IgG. A similar effect of purified non-atopic IgG on TCD8 cells was observed compared with the mock treatment. Atopic IgG inhibited IFN-γ and TGF-β production by intra-thymic TCD4 cells. Treatment with intravenous immunoglobulin resulted in intermediate levels of IFN-γ and TGF-β in intra-thymic TCD4 cells compared with treatment with atopic and non-atopic IgG. Peripheral TCD4 cells from non-atopic individuals produced IFN-γ only in response to atopic IgG. This report describes novel evidence revealing that IgG from atopic individuals may influence intracellular IFN-γ production by intra-thymic αβT cells in a manner that may favor allergy development.

Indexed as

Hypersensitivity, ImmediateCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoculture TechniquesHumansImmunoglobulins, IntravenousImmunologic FactorsInfant, NewbornInterferon-gammaThymocytesThymus GlandIFNG protein, humanImmunoglobulins, IntravenousImmunologic FactorsInterferon-gammaallergyIFN-γIgGthymusαβT cells

Identifiers

PMID28441069
PMCPMC5512811
OpenAlexW2607712933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.