ArticleMuscle & nerve2018
Age-related effect of cell death on fiber morphology and number in tongue muscle.
Article in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Structural and mitochondrial dendritic degenerations in old hypoglossal motor neurons.GeroScience · 2026Article
- Gas1 regulates embryonic tongue muscle proliferation, differentiation and maturation via alternative pathways to Hedgehog signaling.Development (Cambridge, England) · 2025Article
- Association between malnutrition and low tongue pressure in community-dwelling older people: a population-based cohort study.Scientific reports · 2025Article
- Predictors of Difficult Laryngeal Exposure in Suspension Laryngoscopy: A Systematic Review and Meta-Analysis.Clinical and experimental otorhinolaryngology · 2024Article
- Timeline of hypoglossal motor neuron death and intrinsic tongue muscle denervation in high-copy number SOD1Frontiers in neurology · 2024Article
- Sarcopenia of the longitudinal tongue muscles in rats.Respiratory physiology & neurobiology · 2024Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Impact of Limb Phenotype on Tongue Denervation Atrophy, Dysphagia Penetrance, and Survival Time in a Mouse Model of ALS.Dysphagia · 2022Article
- Making the head: Caspases in life and death.Frontiers in cell and developmental biology · 2022Review
- Tongue muscle contractile, fatigue, and fiber type properties in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Tongue and hypoglossal morphology after intralingual cholera toxin B-saporin injection.Muscle & nerve · 2021Article
- Myogenic marker expression as a function of age and exercise-based therapy in the tongue.Experimental gerontology · 2020Article
- Age-related alterations in swallowing biomechanics.Experimental gerontology · 2019Article
- Rehabilitation Nutrition for Iatrogenic Sarcopenia and Sarcopenic Dysphagia.The journal of nutrition, health & aging · 2019Article
- Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis.Frontiers in physiology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMultiple pathways may exist for age-related tongue muscle degeneration. Cell death is one mechanism contributing to muscle atrophy and decreased function. We hypothesized with aging, apoptosis, and apoptotic regulators would be increased, and muscle fiber size and number would be reduced in extrinsic tongue muscles.
methodsCell death indices, expression of caspase-3 and Bcl-2, and measures of muscle morphology and number were determined in extrinsic tongue muscles of young and old rats.
resultsSignificant increases in cell death, caspase-3, and Bcl-2 were observed in all extrinsic tongue muscles along with reductions in muscle fiber number in old rats. DISCUSSION: We demonstrated that apoptosis indices increase with age in lingual muscles and that alterations in apoptotic regulators may be associated with age-related degeneration in muscle fiber size and number. These observed apoptotic processes may be detrimental to muscle function, and may contribute to degradation of cranial functions with age. Muscle Nerve 57: E29-E37, 2018.
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Registered trials
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