ArticleInternational journal of cancer2017
Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium.
Article in International journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reproductive factors and lung cancer risk: a comprehensive systematic review and meta-analysis.BMC public health · 2020Pooled it
- Breastfeeding and subsequent risk of 24 types of maternal cancer: a cohort study of Chinese women.Nutrition journal · 2026Article
- Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study.BMC cancer · 2024Article
- Reproductive Factors in Relation to Incidence of Lung and Colorectal Cancers in a Cohort of Norwegian Women: The HUNT Study.Journal of the Endocrine Society · 2022Article
- Lung cancer trends and tumor characteristic changes over 20 years (2000-2020): Results of three French consecutive nationwide prospective cohorts' studies.The Lancet regional health. Europe · 2022Article
- Evaluating risk factors for lung cancer among never-smoking individuals using two Australian studies.Journal of cancer research and clinical oncology · 2022Article
- Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.Human molecular genetics · 2022Article
- Effect of Refined Perioperative Nursing on the Efficacy of Noninvasive Ventilation in Elderly Patients with Lung Cancer and Respiratory Failure.Journal of oncology · 2022Article
- Menstrual factors, reproductive history, and risk of lung cancer: a multi-center population-based cohort study in Chinese females.Translational lung cancer research · 2021Article
- E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.The Journal of experimental medicine · 2021Article
- Age at first birth and lung cancer: a two-sample Mendelian randomization study.Translational lung cancer research · 2021Article
- The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.Lung cancer (Amsterdam, Netherlands) · 2021Article
- Distinctive lung cancer incidence trends among men and women attributable to the period effect in Shanghai: An analysis spanning 42 years.Cancer medicine · 2020Article
- Body Mass Index (BMI), BMI Change, and Overall Survival in Patients With SCLC and NSCLC: A Pooled Analysis of the International Lung Cancer Consortium.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Article
- Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women.Translational oncology · 2019Article
- Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.Nature communications · 2018Article
- Impact of menopausal status and HER-2/neu protein on efficacy of EGFR-TKI inJournal of Cancer · 2018Article
- A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer.PloS one · 2018Article
- Sex-specific Risks in Lung Cancer-Associated Thrombosis: Focus on Female Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
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22 authors.
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Abstract
Many clinical features of lung cancer are different in women and men. Sex steroid hormones exert effects in nonreproductive organs, such as the lungs. The association between menstrual and childbearing factors and the risk of lung cancer among women is still debated. We performed a pooled analysis of eight studies contributing to the International Lung Cancer Consortium (4,386 cases and 4,177 controls). Pooled associations between menstrual or reproductive factors and lung cancer were estimated using multivariable unconditional logistic regression. Subgroup analyses were done for menopause status, smoking habits and histology. We found no strong support for an association of age at menarche and at menopause with lung cancer, but peri/postmenopausal women were at higher risk compared to premenopausal (OR 1.47, 95% CI 1.11-1.93). Premenopausal women showed increased risks associated with parity (OR 1.74, 95% CI 1.03-2.93) and number of children (OR 2.88, 95% CI 1.21-6.93 for more than 3 children; p for trend 0.01) and decreased with breastfeeding (OR 0.54, 95% CI 0.30-0.98). In contrast, peri/postmenopausal subjects had ORs around unity for the same exposures. No major effect modification was exerted by smoking status or cancer histology. Menstrual and reproductive factors may play a role in the genesis of lung cancer, yet the mechanisms are unclear, and smoking remains the most important modifiable risk factor. More investigations in large well-designed studies are needed to confirm these findings and to clarify the underlying mechanisms of gender differences in lung cancer risk.
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