ArticleInternational journal of molecular medicine2017
Time-dependent differential expression of long non-coding RNAs following peripheral nerve injury.
Article in International journal of molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The etiological roles of miRNAs, lncRNAs, and circRNAs in neuropathic pain: A narrative review.Journal of clinical laboratory analysis · 2022Pooled it
- Hypoxia-induced Schwann cells-derived extracellular vesicles carrying LncRNA TNXA-PS1 promote recovery post sciatic nerve injury.Communications biology · 2026Article
- Characterization of lncRNA and mRNA profiles in the process of repairing peripheral nerve defects with cell-matrixed nerve grafts.BMC genomics · 2024Article
- Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury.Molecular neurobiology · 2024Article
- Long noncoding RNA Pvt1 promotes the proliferation and migration of Schwann cells by sponging microRNA-214 and targeting c-Jun following peripheral nerve injury.Neural regeneration research · 2023Article
- Endocytosis-associated patterns in nerve regeneration after peripheral nerve injury.Journal of orthopaedic translation · 2021Article
- LncRNA SNHG16 promotes Schwann cell proliferation and migration to repair sciatic nerve injury.Annals of translational medicine · 2021Article
- Article
- Up-Regulation of CD146 in Schwann Cells Following Peripheral Nerve Injury Modulates Schwann Cell Function in Regeneration.Frontiers in cellular neuroscience · 2021Article
- Non-coding RNAs in neuropathic pain.Neuronal signaling · 2020Review
- Catecholaminergic axons in the neocortex of adult mice regrow following brain injury.Experimental neurology · 2020Article
- Role of Long Noncoding RNAs and Circular RNAs in Nerve Regeneration.Frontiers in molecular neuroscience · 2019Review
- Long noncoding RNA (lncRNA): a target in neuropathic pain.Expert opinion on therapeutic targets · 2019Review
- Analysis of transcriptome sequencing of sciatic nerves in Sprague-Dawley rats of different ages.Neural regeneration research · 2018Article
- Silencing of circRNA.2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy.Molecular therapy. Nucleic acids · 2018Article
- lncRNA TNXA-PS1 Modulates Schwann Cells by Functioning As a Competing Endogenous RNA Following Nerve Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis.Oncology reports · 2018Article
- Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury.Neural regeneration research · 2017Article
- Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury.Cell reports · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs (lncRNAs) are widely accepted as key players in various biological processes. However, the roles of lncRNA in peripheral nerve regeneration remain completely unknown. Thus, in this study, we performed microarray analysis to measure lncRNA expression in the distal segment of the sciatic nerve at 0, 3, 7 and 14 days following injury. We identified 5,354 lncRNAs that were differentially expressed: 3,788 lncRNAs were differentially expressed between days 0 and 3; 3,314 lncRNAs were differentially expressed between days 0 and 7; and 2,400 lncRNAs were differentially expressed between days 0 and 14. The results of RT-qPCR of two dysregulated lncRNAs were consistent with those of microarray analysis. Bioinformatics approaches, including lncRNA classification, gene ontology (GO) analysis and target prediction, were utilized to investigate the functions of these dysregulated lncRNAs in peripheral nerve damage. Importantly, we predicted that several lncRNA-mRNA pairs may participate in biological processes related to peripheral nerve injury. RT-qPCR was performed for the preliminary verification of three lncRNA‑mRNA pairs. The overexpression of NONMMUG014387 promoted the proliferation of mouse Schwann cells. Thus, the findings of our study may enhance our knowledge of the role of lncRNAs in nerve injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.