ArticleScientific reports2017
Modest and Severe Maternal Iron Deficiency in Pregnancy are Associated with Fetal Anaemia and Organ-Specific Hypoxia in Rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Developmental origins of disease - Effects of iron deficiency in the rat developing kidney and beyond.Pediatric nephrology (Berlin, Germany) · 2026Review
- Phlebotomy-induced anemia reduces oxygen-induced retinopathy severity and dampens retinal developmental transcriptomic pathways in rats.Pediatric research · 2025Article
- Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.Physiological research · 2024Review
- Use of Photoacoustic Imaging to Study the Effects of Anemia on Placental Oxygen Saturation in Normoxic and Hypoxic Conditions.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Unraveling the Role of Maternal Serum Ferritin Levels in Preterm Delivery: A Comprehensive Review.Cureus · 2024Review
- Maternal Iron Deficiency Programs Rat Offspring Hypertension in Relation to Renin-Angiotensin System and Oxidative Stress.International journal of molecular sciences · 2022Article
- A Highly Fluorescent Pyrene-Based Sensor for Selective Detection Of FeJournal of fluorescence · 2022Article
- Food-derived bioactive oligopeptide iron complexes ameliorate iron deficiency anemia and offspring development in pregnant rats.Frontiers in nutrition · 2022Article
- Intermittent Short-Duration Re-oxygenation Attenuates Cardiac Changes in Response to Hypoxia: Histological, Ultrastructural and Oxidant/Antioxidant Parameters.British journal of biomedical science · 2022Article
- Maternal Iron Deficiency Alters Trophoblast Differentiation and Placental Development in Rat Pregnancy.Endocrinology · 2021Article
- Dietary Iron Intake in Excess of Requirements Impairs Intestinal Copper Absorption in Sprague Dawley Rat Dams, Causing Copper Deficiency in Suckling Pups.Biomedicines · 2021Article
- Maternal and Cord Blood Hemoglobin as Determinants of Placental Weight: A Cross-Sectional Study.Journal of clinical medicine · 2021Article
- The relationship between maternal anemia and umbilical cord oxygen content at delivery.American journal of obstetrics & gynecology MFM · 2021Article
- Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects.Frontiers in genetics · 2021Article
- Maternal Iron Deficiency Programs Offspring Cognition and Its Relationship with Gastrointestinal Microbiota and Metabolites.International journal of environmental research and public health · 2020Article
- The Role of Fe, Zn, and Cu in Pregnancy.Biomolecules · 2020Review
- The impact of maternal and early life malnutrition on health: a diet-microbe perspective.BMC medicine · 2020Review
- Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress.Cardiovascular research · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Prenatal iron-deficiency (ID) is known to alter fetal developmental trajectories, which predisposes the offspring to chronic disease in later life, although the underlying mechanisms remain unclear. Here, we sought to determine whether varying degrees of maternal anaemia could induce organ-specific patterns of hypoxia in the fetuses. Pregnant female Sprague Dawley rats were fed iron-restricted or iron-replete diets to induce a state of moderate (M-ID) or severe ID (S-ID) alongside respective controls. Ultrasound biomicroscopy was performed on gestational day (GD)20 to assess uterine and umbilical artery blood flow patterns. On GD21, tissues were collected and assessed for hypoxia using pimonidazole staining. Compared to controls, maternal haemoglobin (Hb) in M- and S-ID were reduced 17% (P < 0.01) and 48% (P < 0.001), corresponding to 39% (P < 0.001) and 65% (P < 0.001) decreases in fetal Hb. Prenatal ID caused asymmetric fetal growth restriction, which was most pronounced in S-ID. In both severities of ID, umbilical artery resistive index was increased (P < 0.01), while pulsatility index only increased in S-ID (P < 0.05). In both M-and S-ID, fetal kidneys and livers showed evidence of hypoxia (P < 0.01 vs. controls), whereas fetal brains and placentae remained normoxic. These findings indicate prenatal ID causes organ-specific fetal hypoxia, even in the absence of severe maternal anaemia.
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