ArticleNature communications2017
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
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Who cites it
81 citing papers in PubMed, 112 citations in OpenAlex.
- Critical Role of Molecular-Based Stratification in Low-Risk Myelodysplastic Syndrome with Direct Progression to Acute Myeloid Leukemia: A Case Report.International journal of molecular sciences · 2026Article
- TET2 in epigenetic control of immune cells: Implications for inflammatory responses and age-related pathologies.The Journal of biological chemistry · 2026Review
- The role of epigenetic modifications in hematological cancers.Frontiers in oncology · 2026Review
- Parallel Evolution of Leukemic Clones in Myeloproliferative Neoplasms.Research square · 2025Article
- Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation.Cell reports · 2025Article
- Article
- The TET protein family interactor PROSER1 sustains hematopoietic stem cell function.Blood advances · 2025Article
- Article
- Evolutionary and structural insights into DNMTs and TETs: decoding their functional heterogeneity and oncogenic roles in methylation regulation.BMC molecular and cell biology · 2025Article
- Prognostic impact of somatic mutations and additional chromosomal abnormalities in patients with myelodysplastic syndromes and chromosome 20q deletion.Clinical and experimental medicine · 2025Article
- Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights.Clinical epigenetics · 2024Review
- The Role of DNMT Methyltransferases and TET Dioxygenases in the Maintenance of the DNA Methylation Level.Biomolecules · 2024Review
- Tet2 is a tumor suppressor in the preleukemic phase of T-cell acute lymphoblastic leukemia.Blood advances · 2024Article
- TET2 mutation as prototypic clonal hematopoiesis lesion.Seminars in hematology · 2024Review
- Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity.Frontiers in immunology · 2024Article
- Common clonal origin of three distinct hematopoietic neoplasms in a single patient: B-cell lymphoma, T-cell lymphoma, and polycythemia vera.Cold Spring Harbor molecular case studies · 2023Article
- TET (Ten-eleven translocation) family proteins: structure, biological functions and applications.Signal transduction and targeted therapy · 2023Review
- TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.Cell stem cell · 2023Article
- Comparative analysis of Tet2 catalytic-deficient and knockout bone marrow over time.Experimental hematology · 2023Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 13 institutions in 2 countries.
Feng PanDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
Thomas S WingoDepartments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
Zhigang ZhaoDepartment of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Rui GaoDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
Hideki MakishimaDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Guangbo QuDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
Li LinDepartments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
Miao YuDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA.
Janice R OrtegaDepartment of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
Jiapeng WangDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Aziz NazhaDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Li ChenDepartments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
Bing YaoDepartments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
Can LiuDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
Shi ChenDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
Ophelia WeeksDepartment of Biological Sciences, Florida International University, Miami, Florida 33199, USA.
Hongyu NiDepartment of Pathology, University of Illinois at Chicago, Chicago, Illinois 60607, USA.
Brittany Lynn PhillipsDepartment of Biochemistry and Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
Suming HuangDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32611, USA.
Jianlong WangDepartment of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Chuan HeDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA.
Guo-Min LiDepartment of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
Tomas RadivoyevitchDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Iannis AifantisHoward Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York 10016, USA.
Jaroslaw P MaciejewskiDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Feng-Chun YangDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
Peng JinDepartments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.ORCID 0000-0001-6137-6659
Mingjiang XuDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
Emory University · USUniversity of Miami · USCleveland Clinic · USSylvester Comprehensive Cancer Center · USUniversity of Chicago · USUniversity of Southern California · USFlorida International University · USHoward Hughes Medical Institute · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineTianjin Medical University Cancer Institute and Hospital · CNUniversity of Florida · USUniversity of Illinois Chicago · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MTRANSLATIONAL RESEARCH ONCOLOGY TRAINING GRANTK12CA076917 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GERSON, STANTON L. · 1997 to 2022
$14.2MRole of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01CA172408 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2024
$3.4MRole of TET2 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01HL112294 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI XU, MINGJIANG · 2012 to 2016
$1.9M5-Hydroxymethylcytosine in NeurodevelopmentR01NS079625 · NINDS · EMORY UNIVERSITY · PI JIN, PENG · 2012 to 2016
$1.7MThe Role of Long Noncoding RNA in HematopoiesisR01DK110108 · NIDDK · UNIVERSITY OF FLORIDA · PI HUANG, SUMING · 2016 to 2019
$1.3MMapping 5-Hydroxymethylcytosine at single-Base Resolution in Human ES CellsR21HD073162 · NICHD · EMORY UNIVERSITY · PI JIN, PENG · 2012 to 2013
$425kA Genetic Study of a Large Pedigree with Late-onset Alzheimer's DiseaseIK2BX001820 · VA · VETERANS HEALTH ADMINISTRATION · PI WINGO, THOMAS SPURGEON · 2014 to 2018
–BLRD VA IK2 BX001820NCI NIH HHS K12 CA076917NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA172408NHLBI NIH HHS R01 HL112294NICHD NIH HHS R21 HD073162NIDDK NIH HHS R01 DK110108NINDS NIH HHS R01 NS079625
Abstract
TET2 is a dioxygenase that catalyses multiple steps of 5-methylcytosine oxidation. Although TET2 mutations frequently occur in various types of haematological malignancies, the mechanism by which they increase risk for these cancers remains poorly understood. Here we show that Tet2
Indexed as
Mutation Rate5-MethylcytosineAgedAnimalsCell Line, TumorDioxygenasesDNA-Binding ProteinsDNA DemethylationDNA Mutational AnalysisEpigenesis, GeneticExome SequencingGene Expression Regulation, NeoplasticHematologic NeoplasmsHematopoietic Stem CellsHumansMice5-hydroxymethylcytosine5-MethylcytosineDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsRNA, Small InterferingTET2 protein, humanTet2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.