Evidence map›Paper›PMID 28440284›Full record

ArticleScientific reports2017

CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue.

Meiyan Dai, Lujin Wu, Peihua Wang, Zheng Wen, Xizhen Xu, Dao Wen Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Multifaceted Role of Macrophages in Biology and Diseases.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Meiyan DaiDivision of Cardiology, Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lujin WuDivision of Cardiology, Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Peihua WangDivision of Cardiology, Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zheng WenDivision of Cardiology, Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xizhen XuDivision of Cardiology, Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dao Wen WangDivision of Cardiology, Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huazhong University of Science and Technology · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages in adipose tissue are associated with obesity-induced low-grade inflammation, which contributed to insulin resistance and the related metabolic diseases. Previous studies demonstrated the beneficial effects of epoxyeicosatrienoic acids (EETs) on metabolic disorders and inflammation. Here we investigated the effects of CYP2J2-EETs-sEH metabolic pathway on insulin resistance in mice and the potential mechanisms. High fat diet (HFD)-induced obesity caused metabolic dysfunction with more weight gain, elevated glucose and lipids levels, impaired glucose tolerance and insulin sensitivity, while increase in EETs level by rAAV-mediated CYP2J2 overexpression, administration of sEH inhibit TUPS or EETs infusion significantly attenuated these metabolic disorders. EETs inhibited macrophages recruitment to adipose tissue and their switch to classically activated macrophage (M1) phenotype, while preserved the alternatively activated macrophage (M2) phenotype, which was accompanied by substantially reduced adipose tissue and systemic inflammation and insulin resistance. In vitro studies further clarified the effects of EETs on macrophage infiltration and polarization, and microarray assays showed that cAMP-EPAC signaling pathway was involved in these processes. Collectively, these results described key beneficial immune-regulatory properties and metabolic regulation of CYP2J2-EETs-sEH metabolic pathway, and indicated therapeutic potential of EETs in obesity-induced insulin resistance and related inflammatory diseases through modulating macrophage polarization targeting cAMP-EPAC signaling pathway.

Indexed as

Insulin ResistanceAdipose TissueAnimalsCells, CulturedCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemDiet, High-FatEicosanoidsGlucoseInsulinMacrophagesMaleMiceMice, Inbred C57BLPhenylurea CompoundsPiperidines1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)ureaCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemEicosanoidsGlucoseInsulinPhenylurea CompoundsPiperidines

Identifiers

PMID28440284
PMCPMC5404269
OpenAlexW2607785892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.