Evidence map›Paper›PMID 28440278›Full record

ReviewNature microbiology2017

An insider's perspective: Bacteroides as a window into the microbiome.

Aaron G Wexler, Andrew L Goodman

Open access · greenAbstract readReview
In one paragraph

Review in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 355 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
355citing papers in PubMed, 2 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

355 citing papers in PubMed, 2 syntheses or guidelines pooled it, 647 citations in OpenAlex.

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295 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aaron G WexlerDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Andrew L GoodmanDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Causes and consequences of interpersonal microbial variationR35GM118159 · NIGMS · YALE UNIVERSITY · PI Andrew L Goodman · 2016 to 2026
$5.6M
Defining the contribution of interpersonal microbial variation to drug metabolismDP2GM105456 · NIGMS · YALE UNIVERSITY · PI GOODMAN, ANDREW L · 2012 to 2017
$3.0M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS DP2 GM105456NIGMS NIH HHS R35 GM118159
6 · The paper itself

Abstract

Over the last decade, our appreciation for the contribution of resident gut microorganisms-the gut microbiota-to human health has surged. However, progress is limited by the sheer diversity and complexity of these microbial communities. Compounding the challenge, the majority of our commensal microorganisms are not close relatives of Escherichia coli or other model organisms and have eluded culturing and manipulation in the laboratory. In this Review, we discuss how over a century of study of the readily cultured, genetically tractable human gut Bacteroides has revealed important insights into the biochemistry, genomics and ecology that make a gut bacterium a gut bacterium. While genome and metagenome sequences are being produced at breakneck speed, the Bacteroides provide a significant 'jump-start' on uncovering the guiding principles that govern microbiota-host and inter-bacterial associations in the gut that will probably extend to many other members of this ecosystem.

Indexed as

BacteroidesMetagenomeMicrobiotaBacillotaGastrointestinal MicrobiomeGastrointestinal TractGenomicsHigh-Throughput Nucleotide SequencingHumansSymbiosis

Identifiers

PMID28440278
PMCPMC5679392
OpenAlexW2609317492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.