Evidence map›Paper›PMID 28440221›Full record

ArticleeLife2017

NPTX2 and cognitive dysfunction in Alzheimer's Disease.

Mei-Fang Xiao, Desheng Xu, Michael T Craig, Kenneth A Pelkey, Chun-Che Chien, Yang Shi, Juhong Zhang, Susan Resnick, Olga Pletnikova, David Salmon and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 3 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 3 syntheses or guidelines pooled it, 321 citations in OpenAlex.

  1. Pooled it
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  5. Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Mei-Fang XiaoSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Desheng XuSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Michael T CraigProgram in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, Bethesda, United States.ORCID 0000-0001-8481-6709
Kenneth A PelkeyProgram in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, Bethesda, United States.
Chun-Che ChienSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Yang ShiSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Juhong ZhangSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Susan ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, United States.
Olga PletnikovaDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States.
David SalmonDepartment of Neurosciences, University of California San Diego Medical Center, San Diego, United States.
James BrewerDepartment of Neurosciences, University of California San Diego Medical Center, San Diego, United States.
Steven EdlandShiley-Marcos Alzheimer's Disease Research Center, University of California San Diego Medical Center, San Diego, United States.ORCID 0000-0002-1153-7335
Jerzy WegielInstitute for Basic Research, New York City, United States.
Benjamin TyckoTaub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University, New York City, United States.
Alena SavonenkoDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States.
Roger H ReevesDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, United States.
Juan C TroncosoDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States.
Chris J McBainProgram in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, Bethesda, United States.
Douglas GalaskoDepartment of Neurosciences, University of California San Diego Medical Center, San Diego, United States.
Paul F WorleySolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-5086-614X
Johns Hopkins University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of California San Diego Medical Center · USColumbia University · USInstitute on Aging · USUniversity of California San Diego · US

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
Cellular And Synaptic Physiology Of Hippocampal InterneuronsZIAHD001205 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MCBAIN, CHRIS J. · 2009 to 2025
$45.8M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Early Markers of Alzheimer DiseaseZIAAG000185 · NIA · NATIONAL INSTITUTE ON AGING · PI WALKER, KEENAN · 2009 to 2025
$20.4M
GENOMIC APPROACHES TO ANEUPLOIDYR01HD038384 · NICHD · JOHNS HOPKINS UNIVERSITY · PI REEVES, ROGER H · 2000 to 2020
$11.0M
Semaphorin Signaling and Plasticity at the Excitatory SynapseP50MH100024 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 2013 to 2017
$9.5M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VALLE, DAVID · 2014 to 2019
$7.9M
De novo Synthesis and MemoryR35NS097966 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WORLEY, PAUL F · 2017 to 2024
$4.3M
NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005146NICHD NIH HHS R01 HD038384NICHD NIH HHS U54 HD079123NIMH NIH HHS P50 MH100024NINDS NIH HHS R35 NS097966
6 · The paper itself

Abstract

Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spiking parvalbumin (PV) interneurons that control network excitability and rhythmicity. Excitatory synapses on PV interneurons are dependent on the AMPA receptor subunit GluA4, which is regulated by presynaptic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neurons. In a mouse model of AD amyloidosis,

Indexed as

Alzheimer DiseaseAnimalsCerebral CortexCognitive DysfunctionC-Reactive ProteinDisease Models, AnimalHippocampusHumansMiceMice, KnockoutNerve Tissue ProteinsPentraxinsC-Reactive ProteinNerve Tissue ProteinsPentraxinsalzheimer’s diseaseAlzheimer's diseasedementiaimmediate early geneinhibitory neuronmmediate early geneneuroscience

Identifiers

PMID28440221
PMCPMC5404919
OpenAlexW2606988847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.